METHYL 4-THIAZOLECARBOXYLATE synthesis
- Product Name:METHYL 4-THIAZOLECARBOXYLATE
- CAS Number:59418-09-6
- Molecular formula:C5H5NO2S
- Molecular Weight:143.16
42258-90-2
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Yield:59418-09-6 80.8%
Reaction Conditions:
with manganese(IV) oxide in acetonitrile at 50; for 36 h;Temperature;
Steps:
1.3; 2.3; 3.3; 4.3; 5.3; 6.3 3. Synthesis of methyl thiazole-4-carboxylate
Add 3.09 (0.02 mol) of thiazolidine-4-carboxylic acid methyl ester, 175 mL of acetonitrile to a 250 mL four-necked flask.40.0 g (0.46 mol) of MnO2 after activation at 300 °C.The reaction was carried out at 50 ° C for 36 h (GC followed the progress of the reaction).After cooling, it was filtered, and the filtrate was evaporated under reduced pressure to remove solvent.Methyl thiazole-4-carboxylate 2.369 was obtained in a yield of 80.8%.
References:
CN109574953,2019,A Location in patent:Paragraph 0021; 0026-0027; 0031; 0036-0037; 0041; 0046-0047
67-56-1
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60667-24-5
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