4-Methylthiazole-5-carboxylic acid synthesis
- Product Name:4-Methylthiazole-5-carboxylic acid
- CAS Number:20485-41-0
- Molecular formula:C5H5NO2S
- Molecular Weight:143.16
77287-34-4
609-15-4
20485-41-0
A mechanical stirrer, thermometer and constant pressure dropping funnel were assembled in a 10 L glass reactor and 1 mole of phosphorus pentasulfide (P4S10) and 6 kg of ethylene glycol dimethyl ether were added as solvent under nitrogen protection. Under stirring conditions, 5 moles of formamide was slowly added dropwise and the reaction lasted for 2 hours. Subsequently, 5 moles of ethyl 2-chloroacetoacetate was added dropwise and the reaction was carried out at room temperature for 608 hours. Upon completion of the reaction, the reaction mixture was cooled to 10 °C and the white solid product was collected by filtration. The solid product was dissolved in 4 times its weight in water and the pH was adjusted to 7-8 with 20% sodium hydroxide solution. filtration at 0-5 °C gave ethyl 4-methylthiazole-5-carboxylate as a white solid with 99% purity and 95.8% molar yield.
1977-06-6
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$64.00/250 mg
82294-70-0
295 suppliers
$6.00/1g
20485-41-0
220 suppliers
$6.00/1g
Yield:82294-70-0 72% ，20485-41-0 15%
Reaction Conditions:
with sodium hypochlorite;N-oxyl-immobilized silica gel in acetone at 0; for 2 h;
References:
Tanaka, Hideo;Chou, Jingyu;Mine, Machiko;Kuroboshi, Manabu [Bulletin of the Chemical Society of Japan,2004,vol. 77,# 9,p. 1745 - 1755]
20582-55-2
208 suppliers
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20485-41-0
220 suppliers
$6.00/1g
137-00-8
534 suppliers
$8.00/10g
20485-41-0
220 suppliers
$6.00/1g
57658-34-1
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20485-41-0
220 suppliers
$6.00/1g