(1S,3S)-2,3,4,9-TETRAHYDRO-1-METHYL-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID synthesis
- Product Name:(1S,3S)-2,3,4,9-TETRAHYDRO-1-METHYL-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID
- CAS Number:40678-46-4
- Molecular formula:C13H14N2O2
- Molecular Weight:230.26
75-07-0
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73-22-3
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40678-46-4
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$501.25/5MG
Yield:40678-46-4 91%
Reaction Conditions:
with sulfuric acid in water at 20;
Steps:
1-1 Step 1-1. Synthesis of (1S,3S)-1-Methyl-2,3,4,9-tetrahydro-1H-pyrido-[3,4-b]indole-3-carboxylic acid:
Add 0.5mL concentrated H2SO4 and 40% acetaldehyde aqueous solution (3.5mL, 24.5mmol,1.0 eq) then L-tryptophan (5.0 g, 24.5 mmol, 1.0 eq) was added.The mixture was stirred at room temperature overnight, adjusted to pH=6-7 with 1mol/L sodium hydroxide,A white solid precipitated. Filter the white slurry,The filter cake was washed three times with water to obtain a white solid (5.1 g, 91%).
References:
CN111303148,2020,A Location in patent:Paragraph 0037
75-07-0
430 suppliers
$14.00/5mL
73-22-3
1021 suppliers
$5.00/250mg
40678-46-4
20 suppliers
$501.25/5MG
![(1R,3S)-2,3,4,9-Tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-3-carboxylic acid](/CAS/20200611/GIF/42438-72-2.gif)
42438-72-2
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![2,3,4,9-Tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1,3-dicarboxylic Acid](/CAS/20200331/GIF/CB25211683.gif)
18070-61-6
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40678-46-4
20 suppliers
$501.25/5MG
73-22-3
1021 suppliers
$5.00/250mg
40678-46-4
20 suppliers
$501.25/5MG