ChemicalBook CAS DataBase List (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE

(5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE synthesis

6synthesis methods

Product Name:(5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE
CAS Number:444335-16-4
Molecular formula:C10H9BrFNO3
Molecular Weight:290.09

(R)-3-(3-FLUOROPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONE

149524-42-5
94 suppliers
$34.00/100mg

(5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE

444335-16-4
195 suppliers
$8.00/250mg

Yield:444335-16-4 92%

Reaction Conditions:

with silver trifluoroacetate;bromine chloride in acetonitrile at 20; for 24 h;

Steps:

2.3 (R) -3- (4-bromo-3-fluorophenyl) -2-oxo-5-oxazolidinylmethanol(Formula 5-a)

Will be 30 grams(R) -3- (3-fluorophenyl) -2-oxo-5-oxazolidinylmethanolDissolved in 300 ml of acetonitrile,And will be 46 gramsSilver trifluoroacetate(CF3COOAg) and 30.5 g of BrCl were added to the solution,After stirring at room temperature for 1 day, water was added to the solution and extracted with ethyl acetate. The resulting organic layer was separated and washed with brine and dehydrated. The residue was then filtered, concentrated in vacuo and dried, yielding 37.8 g of the title compound in 92% yield.

References:

CN106146559,2016,A Location in patent:Paragraph 0044; 0046

510729-01-8 Synthesis