ChemicalBook CAS DataBase List 5-BROMO-2-(2-METHYL-2H-TETRAZOL-5-YL)-PYRIDINE

5-BROMO-2-(2-METHYL-2H-TETRAZOL-5-YL)-PYRIDINE synthesis

6synthesis methods

Product Name:5-BROMO-2-(2-METHYL-2H-TETRAZOL-5-YL)-PYRIDINE
CAS Number:380380-64-3
Molecular formula:C7H6BrN5
Molecular Weight:240.06

380380-60-9

50-00-0

5-BROMO-2-(2-METHYL-2H-TETRAZOL-5-YL)-PYRIDINE

380380-64-3

1. 5-Bromo-2-(2H-tetrazol-5-yl)pyridine (226 g), formaldehyde (90 g) and 10% palladium-carbon catalyst (20 g) were added to a reactor in 1.5 L of methanol. 2. The reaction was stirred at room temperature under hydrogen atmosphere (0.2 MPa) for 3 h. 3. Upon completion of the reaction, the organic phase was removed by evaporation. 4. The residue was recrystallized using acetonitrile to afford the target product 2-methyl-5-(5-bromo-2-pyridinyl)tetrazole (217 g) in 90.4% yield.

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50-00-0 Synthesis

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Yield:380380-64-3 90.4%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol at 20; under 1500.15 Torr; for 3 h;

Steps:

1 Preparation of 2-methyl-5- (5-bromopyridin-2-yl) tetrazole

1.5 L of methanol,5-bromo-2- (2H-tetrazol-5-yl) pyridine (226 g)Formaldehyde (90g),10% palladium on carbon (20 g) was added to the reactor,Under a hydrogen atmosphere (0.2 MPa)Stirred at room temperature for 3 hours, the reaction was completed,Organic phase evaporated,Recrystallization from acetonitrile,To give the product 2-methyl-5- (5-bromo-2-yl) tetrazolium,217 g, yield: 90.4%.

References:

CN106632240,2017,A Location in patent:Paragraph 0018-0019

380380-60-9
126 suppliers
$43.00/250mg