cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid synthesis
- Product Name:cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid
- CAS Number:471905-41-6
- Molecular formula:C21H21ClF2O4S
- Molecular Weight:442.9
656810-86-5
1 suppliers
inquiry
7758-19-2
296 suppliers
$43.39/500 G
5329-14-6
517 suppliers
$13.50/100G
471905-41-6
99 suppliers
$28.00/1unit
Yield:471905-41-6 74%
Reaction Conditions:
in dichloromethane;water
Steps:
98 Method (b)
Method (b) To a solution of crude cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanal (Example 97, method (b)) (650 g, 1.52 mol) in CH2Cl2 (6 L) and H2O (6L) was added sulfamic acid (215.5 g, 2.21 mol) followed by slow addition of sodium chlorite (180 g in 3.13L H2O, 2.0 mol) over 30 min. maintaining the internal temperature below 30° C. The phases were separated and the organic layer was washed with an aqueous Na2S2O5 solution (157 g in 20L H2O), water (20L) and then dried (Na2SO4). The solution was concentrated in vacuo and the residue was recrystallized from IPAc/heptane to afford cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid (482 g, 74%).
References:
Churcher, Ian;Dinnell, Kevin;Harrison, Timothy;Kerrad, Sonia;Nadin, Alan John;Oakley, Paul Joseph;Shaw, Duncan Edward;Teall, Martin Richard;Williams, Susannah;Williams, Brian John US2003/114496, 2003, A1
106-54-7
254 suppliers
$10.00/5g
471905-41-6
99 suppliers
$28.00/1unit
656810-86-5
1 suppliers
inquiry
471905-41-6
99 suppliers
$28.00/1unit
470716-52-0
9 suppliers
$437.00/1g
471905-41-6
99 suppliers
$28.00/1unit
470716-51-9
29 suppliers
$446.00/1g
471905-41-6
99 suppliers
$28.00/1unit