5-(2-methylphenyl)-4H-1,2,4-triazole-3-thiol synthesis

5synthesis methods

Product Name:5-(2-methylphenyl)-4H-1,2,4-triazole-3-thiol
CAS Number:54294-18-7
Molecular formula:C9H9N3S
Molecular Weight:191.26

2-(2-Methylbenzoyl)hydrazinecarbothioaMide

7653-33-0
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5-(2-methylphenyl)-4H-1,2,4-triazole-3-thiol

54294-18-7
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Yield:54294-18-7 82.58%

Reaction Conditions:

with water monomer;sodium hydroxide at 100; for 6 h;

Steps:

1.2 Step 2: Preparation of intermediates 1b-18b (second intermediate)

1 g (4.78 mmol) of intermediate 1a was placed in 20 mL of water, 1.91 g (47.8 mmol) of sodium hydroxide was added, and the reaction was heated and stirred at 100 ° C. for 6 h.After the reaction was completed, the mixture was cooled to room temperature, and the pH was adjusted to 5 to 6 with dilute hydrochloric acid to precipitate a large amount of white powder.Filtration and vacuum drying gave Intermediate 1b, yield: 82.58%.

References:

CN110818648,2020,A Location in patent:Paragraph 0102; 0106-0107

7658-80-2 Synthesis