ChemicalBook CAS DataBase List o-Toluic acid

o-Toluic acid synthesis

15synthesis methods

Product Name:o-Toluic acid
CAS Number:118-90-1
Molecular formula:C8H8O2
Molecular Weight:136.15

89-95-2 Synthesis

89-95-2
203 suppliers
$22.00/10g

118-90-1
484 suppliers
$13.00/1g

Yield:118-90-1 97%

Reaction Conditions:

with picoline;tert.-butylhydroperoxide;chlorophyllin in water at 80; for 15 h;chemoselective reaction;

Steps:

3.1. General Procedure for the Selective Oxidation of Benzyl Alcohols Catalyzed by SCC

General procedure: A solution of benzyl alcohol (1 mmol), SCC (1 mol %), 70% TBHP (1 mmol or 3 mmol),and 4-methylpyridine (1.0 mmol) in H2O (2 mL) was stirred at 60 °C (or 80 °C) for 10 h (or 15 h).The reaction mixture was quenched with a saturated solution of sodium thiosulfate (5 mL) andextracted using dichloromethane (3 10 mL). The combined organic layers were dried over anhydrous Na2SO4, filtrated, and then the solvent was removed under reduced pressure. The residue was purified by flash column chromatography on silica gel with petroleum ether/ethyl acetate as the eluent to obtain the desired product.

References:

Liu, Shi-juan;Zhang, Miao;Lu, Rong;Li, Xiu-ying;Che, Guang-bo [Molecules,2018,vol. 23,# 8,art. no. 1883]