ChemicalBook CAS DataBase List 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine

5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine synthesis

10synthesis methods

Product Name:5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
CAS Number:1180132-17-5
Molecular formula:C12H20N4
Molecular Weight:220.31

5308-25-8 Synthesis

5308-25-8
441 suppliers
$15.00/5G

70258-18-3 Synthesis

70258-18-3
497 suppliers
$5.00/5g

5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine

1180132-17-5
187 suppliers
$25.00/250mg

Yield:1180132-17-5 94%

Reaction Conditions:

at 60 - 70; for 2 h;Green chemistry;Time;

Steps:

1 Example 1 Synthesis of 1-(6-chloro-pyridin-3-ylmethyl)-4-ethyl-piperazine (II)

2-Chloro-5-chloromethylpyridine (162 g, 1.0 mol), tap water 300 mL, and N-ethylpiperazine (171 g, 1.5 mol) were added to a 1 L reaction flask.Raise to 60-70 ° C, stir for 2 h, cool to room temperature,Potassium carbonate (138 g, 1.0 mol) was added and stirred for 10 minutes, the aqueous phase was separated, and dried to give 225 g of product, yield 94%.

References:

CN108440401,2018,A Location in patent:Paragraph 0014; 0032-0040; 0047; 0048

5308-25-8 Synthesis

5308-25-8
441 suppliers
$15.00/5G