
5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine synthesis
- Product Name:5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine
- CAS Number:1180132-17-5
- Molecular formula:C12H20N4
- Molecular Weight:220.31

5308-25-8
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70258-18-3
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1180132-17-5
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Yield:1180132-17-5 94%
Reaction Conditions:
at 60 - 70; for 2 h;Green chemistry;Time;
Steps:
1 Example 1 Synthesis of 1-(6-chloro-pyridin-3-ylmethyl)-4-ethyl-piperazine (II)
2-Chloro-5-chloromethylpyridine (162 g, 1.0 mol), tap water 300 mL, and N-ethylpiperazine (171 g, 1.5 mol) were added to a 1 L reaction flask.Raise to 60-70 ° C, stir for 2 h, cool to room temperature,Potassium carbonate (138 g, 1.0 mol) was added and stirred for 10 minutes, the aqueous phase was separated, and dried to give 225 g of product, yield 94%.
References:
CN108440401,2018,A Location in patent:Paragraph 0014; 0032-0040; 0047; 0048

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1180132-17-5
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121-44-8
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1180132-17-5
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![Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl-](/CAS/20150408/GIF/1231930-25-8.gif)
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1180132-17-5
221 suppliers
$25.00/250mg

5308-25-8
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$15.00/5G

1180132-17-5
221 suppliers
$25.00/250mg