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78706-26-0

5,7-DICHLORO-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE synthesis

2synthesis methods
40775-75-5 Synthesis
5-HYDROXY-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-OL

40775-75-5
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Yield:78706-26-0 68%

Reaction Conditions:

with trichlorophosphate in N,N-dimethyl-aniline; for 1.5 h;Reflux;

References:

Gujjar, Ramesh;El Mazouni, Farah;White, Karen L.;White, John;Creason, Sharon;Shackleford, David M.;Deng, Xiaoyi;Charman, William N.;Bathurst, Ian;Burrows, Jeremy;Floyd, David M.;Matthews, David;Buckner, Frederick S.;Charman, Susan A.;Phillips, Margaret A.;Rathod, Pradipsinh K. [Journal of Medicinal Chemistry,2011,vol. 54,# 11,p. 3935 - 3949] Location in patent:experimental part

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