5-AMino-1-cyclopentyl-1H-pyrazole-4-carbonitrile synthesis
- Product Name:5-AMino-1-cyclopentyl-1H-pyrazole-4-carbonitrile
- CAS Number:30929-67-0
- Molecular formula:C9H12N4
- Molecular Weight:176.22
Yield:30929-67-0 85%
Reaction Conditions:
Stage #1: cyclopentylhydrazine hydrochloridewith triethylamine in ethanol at 0; for 2 h;
Stage #2: Ethoxymethylenemalononitrile in ethanol at 20; for 6 h;Reflux;
Steps:
3 Synthesis of intermediate M-5
(300 mg, 2.2 mmol) was dissolved in 2 mL of ethanol, triethylamine (707 mg, 7 mmol) was slowly added at 0 ° C,Reaction for 2 hA solution of ethoxymethylenemalononitrile (244 mg, 2 mmol) in ethanol was added dropwise to the mixture,After 3 h reaction at room temperature, continueReflux heating 3 h. After monitoring the reaction,Water was slowly added to the reaction system until a brown solid appeared, washed three times with water, three times with ether: n-hexane (1: 1) to give brown solid (299 mg, 85%).
References:
CN106977518,2017,A Location in patent:Paragraph 0022
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