5-BENZOXAZOLOL, 2-METHYL- synthesis
- Product Name:5-BENZOXAZOLOL, 2-METHYL-
- CAS Number:23997-94-6
- Molecular formula:C8H7NO2
- Molecular Weight:149.15
24558-42-7
23997-94-6
The general procedure for the synthesis of 5-hydroxy-2-methylbenzoxazole from the compound (CAS: 24558-42-7) was as follows: compound 2 (20.0 g, 119.7 mmol) was dissolved in N,N-dimethylformamide (DMF, 300 mL) and the solution was cooled to 0 °C. Phosphorus oxychloride (POCl3, 20 g, 131.6 mmol) was slowly added dropwise while keeping the internal temperature below 10 °C. After the dropwise addition, the reaction mixture was continued to be stirred at 0°C for 1 hour. After completion of the reaction, water (1 L) was added to the reaction mixture and extracted with ethyl acetate (EA, 300 mL x 3). The organic phases were combined and concentrated. The concentrated residue was dissolved in methyl tert-butyl ether (MTBE, 800 mL) and washed with deionized water (200 mL × 3). The organic layer was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated. Finally, the residue was washed with a solvent mixture of dichloromethane (DCM) and petroleum ether (PE) (4:1, 250 mL, v/v) to afford compound 3 (13.5 g, 75.6% yield).
490-78-8
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23997-94-6
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$26.00/100mg
Yield:23997-94-6 77%
Reaction Conditions:
with trifluorormethanesulfonic acid;trimethylsilylazide in dichloromethane at 20;
References:
Nimnual, Phongprapan;Tummatorn, Jumreang;Thongsornkleeb, Charnsak;Ruchirawat, Somsak [Journal of Organic Chemistry,2015,vol. 80,# 17,p. 8657 - 8667]
24558-42-7
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23997-94-6
69 suppliers
$26.00/100mg
24558-42-7
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23997-94-6
69 suppliers
$26.00/100mg
79-24-3
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$353.45/5gm:
123-31-9
854 suppliers
$13.00/25g
23997-94-6
69 suppliers
$26.00/100mg
23997-82-2
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23997-94-6
69 suppliers
$26.00/100mg