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2',5'-Dihydroxyacetophenone

2',5'-Dihydroxyacetophenone structure

CAS No.: 490-78-8

Chemical Name:: 2',5'-Dihydroxyacetophenone

Synonyms: 2,5-DIHYDROXYACETOPHENONE;1-(2,5-DIHYDROXYPHENYL)ETHAN-1-ONE;1-(2,5-DIHYDROXYPHENYL)ETHANONE;Ethanone, 1-(2,5-dihydroxyphenyl)-;2-hydroxy-1-(3-hydroxyphenyl)ethan-1-one;2,5-DHAP;ACETYLQUINOL;WLN: QR CQ BV1;QUINACETOPHENONE;Acetylhydroquinone

CBNumber:: CB8221168

Molecular Formula:: C8H8O3

Molecular Weight:: 152.15

MDL Number:: MFCD00002343

MOL File:: 490-78-8.mol

MSDS File:: SDS

Last updated:2023-08-25 11:46:16

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2',5'-Dihydroxyacetophenone Properties

Melting point	204-206 °C(lit.)
Boiling point	234.6°C (rough estimate)
Density	1.2143 (rough estimate)
refractive index	1.4447 (estimate)
storage temp.	Store below +30°C.
solubility	dioxane: 50 mg/mL, clear
form	Crystals or Crystalline Powder
pka	9.86±0.18(Predicted)
color	Yellow to yellow-green
Water Solubility	insoluble
BRN	637903
InChIKey	WLDWSGZHNBANIO-UHFFFAOYSA-N
LogP	1.274 (est)
CAS DataBase Reference	490-78-8(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	K1H7QH11ZH
NIST Chemistry Reference	Ethanone, 1-(2,5-dihydroxyphenyl)-(490-78-8)
EPA Substance Registry System	Ethanone, 1-(2,5-dihydroxyphenyl)- (490-78-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

RTECS

AM7700000

Hazard Note

Irritant

TSCA

Yes

HS Code

29145000

NFPA 704

	0
2		0

2',5'-Dihydroxyacetophenone price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D107603	2′,5′-Dihydroxyacetophenone 97%	490-78-8	25g	$70.8	2024-03-01	Buy
Sigma-Aldrich	8.18284	2′,5′-Dihydroxyacetophenone for synthesis	490-78-8	10g	$97.2	2024-03-01	Buy
Sigma-Aldrich	8.18284	2',5'-Dihydroxyacetophenone for synthesis. CAS 490-78-8, chemical formula 2,5-(OH) -C H COCH ., for synthesis	490-78-8	8182840010	$74.7	2021-12-16	Buy
TCI Chemical	D1955	2',5'-Dihydroxyacetophenone >98.0%(GC)	490-78-8	5g	$54	2024-03-01	Buy
TCI Chemical	D1955	2',5'-Dihydroxyacetophenone >98.0%(GC)	490-78-8	25g	$187	2024-03-01	Buy

Product number	Packaging	Price	Buy
D107603	25g	$70.8	Buy
8.18284	10g	$97.2	Buy
8.18284	8182840010	$74.7	Buy
D1955	5g	$54	Buy
D1955	25g	$187	Buy

2',5'-Dihydroxyacetophenone Chemical Properties,Uses,Production

Description

2',5'-Dihydroxyacetophenone is a natural phenolic compound that is found in many plants. It has been shown to have anti-inflammatory properties through its ability to inhibit the production of pro-inflammatory cytokines, such as tumor necrosis factor alpha and interleukin 1 beta.

Chemical Properties

yellow to yellow-green crystals or

Uses

1-(2,5-Dihydroxyphenyl)ethanone is an intermediate used in various synthetic preparations of pharmaceutical goods, 1-(2,5-Dihydroxyphenyl)ethanone was untilized in the synthesis of new flavonoid fatty acid esters with anti-adipogenic and glucose consumption enhancing activities.

Uses

2',5'-Dihydroxyacetophenone is an intermediate used in various synthetic preparations of pharmaceutical goods, 1-(2,5-Dihydroxyphenyl)ethanone was untilized in the synthesis of new flavonoid fatty acid esters with anti-adipogenic and glucose consumption enhancing activities.

Application

2',5'-Dihydroxyacetophenone inhibits the formation of reactive oxygen species and nitric oxide in rat neutrophils. It also has the ability to reduce oxidative stress by scavenging free radicals and inhibiting lipid peroxidation. The underlying mechanism for these effects is not fully understood but may be due to its ability to act as a substrate for matrix-assisted laser desorption ionization (MALDI). This means that it can react with protocatechuic acid molecules that are present in the sample preparation chamber, leading to polymerase chain reaction (PCR) amplification.

Definition

ChEBI: 2',5'-Dihydroxyacetophenone is an aromatic ketone.

Preparation

Preparation by Fries rearrangement of hydroquinone diacetate,
with aluminium chloride(91%) (76%)(63–77%) (55–60%)
with zinc chloride in refluxing acetic acid (quantitative yield)
with boron trifluoride etherate in benzene at reflux (65%).

Synthesis Reference(s)

The Journal of Organic Chemistry, 18, p. 1709, 1953 DOI: 10.1021/jo50018a014

2',5'-Dihydroxyacetophenone synthesis

Synthesis of 2',5'-Dihydroxyacetophenone from Acetic anhydride and Hydroquinone

2',5'-Dihydroxyacetophenone Preparation Products And Raw materials

Raw materials

1,4-Diacetoxybenzene Aluminium chloride hexahydrate

Preparation Products

3,6-DIHYDROXYFLAVONE 6-Hydroxy-4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl ester

2',5'-Dihydroxyacetophenone Suppliers

Global( 380)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88299272	info@edengenechem.com	China	2169	58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd	029-81140587 +8618717328141	sales@yutbon.com	China	437	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2141	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58

Supplier	Advantage
Changzhou Ditong Chemical Co.,Ltd	58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Hebei Mojin Biotechnology Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Hubei Jusheng Technology Co.,Ltd.	58
Accela ChemBio Inc.	58
Hebei Guanlang Biotechnology Co., Ltd.	58

View Lastest Price from 2',5'-Dihydroxyacetophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-08-26	2',5'-Dihydroxyacetophenone 490-78-8	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2023-03-06	2',5'-Dihydroxyacetophenone 490-78-8	US $10.70 / Kg/Bag	10g	99%	10000kg	Hebei Guanlang Biotechnology Co,.LTD
2022-09-30	2',5'-Dihydroxyacetophenone 490-78-8	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.

2',5'-Dihydroxyacetophenone
490-78-8
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

2',5'-Dihydroxyacetophenone
490-78-8
US $10.70 / Kg/Bag
99%
Hebei Guanlang Biotechnology Co,.LTD

2',5'-Dihydroxyacetophenone
490-78-8
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

2',5'-Dihydroxyacetophenone Spectrum

2',5'-Dihydroxyacetophenone(490-78-8)MS 2',5'-Dihydroxyacetophenone(490-78-8)¹HNMR 2',5'-Dihydroxyacetophenone(490-78-8)¹³CNMR 2',5'-Dihydroxyacetophenone(490-78-8)IR1 2',5'-Dihydroxyacetophenone(490-78-8)IR2

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1of4

1-(2,5-dihydroxyphenyl)-ethanon 1-Acetyl-2,5-dihydroxybenzene 2,5-Dihydroxy-1-acetylbenzene 2’,5’-dihydroxy-acetophenon Acetophenone, 2',5'-dihydroxy- Acetylhydroquinone QUINACETOPHENONE 2-Acetylhydroquinone Quinacetophenone 2',5'-DIHYDROXYACETOPHENONE FOR SYNTHESI 1-(2,5-Dihydroxyphenyl)ethan-1-one, 2-Acetylhydroquinone 2,5- twohydroxyAcetophenone WLN: QR CQ BV1 ACETYLQUINOL 2,5-DIHYDROXYPHENYL METHYL KETONE 2',5'-DIHYDROXYACETOPHENONE 2-ACETYL-1,4-DIHYDROXYBENZENE 2-ACETYLHYDROQUINONE 2',5'-Dihydroxyacetophenone 2-Acetylhydroquinone 2,5-Dihydroxyacetophenone, 98+% 2-Acethylhydroquinone 2,5-DIHYDROXYACETOPHENONE extrapure 2,5-Dihydroxyphenyl methyl ketone, 2-Acetyl-1,4-dihydroxybenzene, 2-Acetylhydroquinone, Acetylquinol, Quinacetophenone 2',5'-Dihydroxyacetophenone,97% 2',5'- Dihydroxyacetophnone 2′,5′-Dihydroxyacetophenone,2,5-Dihydroxyphenyl methyl ketone, 2-Acetyl-1,4-dihydroxybenzene, 2-Acetylhydroquinone, Acetylquinol, Quinacetophenone 2',5'-Dihydroxyaceto 2 ', 5'-hydroxyacetophenone 5'-Dihydroxyacetophenone 2',5'-Dihydroxyacetophenone> 2,5-DHAP 2,5-Dihydroxy-Acetophenone (Quinacetophenone -98 %) 2,5-DIHYDROXYACETOPHENONE 1-(2,5-DIHYDROXYPHENYL)ETHAN-1-ONE 1-(2,5-DIHYDROXYPHENYL)ETHANONE Ethanone, 1-(2,5-dihydroxyphenyl)- 2-hydroxy-1-(3-hydroxyphenyl)ethan-1-one 2',5'- Di hyfeoxy acetophenone 2',5'-Dihydroxyacetophenone(Quinactophenone) 2',5'-Dihydroxyacetophenone, ≥ 98.0% 2',5'-Dihydroxyacetophenone 490-78-8 490-78-9 HO2C6H3COCH3 BioChemical Building Blocks C7 to C8 Carbonyl Compounds Mass Spectrometry Matrices for MALDI Analysis Ketones Organic Building Blocks Protein Analysis Proteomics and Protein Expression KETONE Building Blocks C7 to C8 Carbonyl Compounds Chemical Synthesis