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Hydroquinone

Hydroquinone
Hydroquinone structure
CAS No.
123-31-9
Chemical Name:
Hydroquinone
Synonyms
HQ;he5;HE 5;Artra;diak5;QUINOL;Diak 5;Melanex;tenoxhq;Phiaquin
CBNumber:
CB6717931
Molecular Formula:
C6H6O2
Formula Weight:
110.11
MOL File:
123-31-9.mol

Hydroquinone Properties

Melting point:
172-175 °C(lit.)
Boiling point:
285 °C(lit.)
Density 
1.32
vapor density 
3.81 (vs air)
vapor pressure 
1 mm Hg ( 132 °C)
refractive index 
1.6320
Flash point:
165 °C
storage temp. 
Refrigerator
solubility 
H2O: 50 mg/mL, clear
pka
10.35(at 20℃)
form 
Needle-Like Crystals or Crystalline Powder
color 
White to off-white
Water Solubility 
70 g/L (20 ºC)
Sensitive 
Air & Light Sensitive
Merck 
14,4808
BRN 
605970
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, oxygen, ferric salts. Light and air-sensitive. Discolours in air.
InChIKey
QIGBRXMKCJKVMJ-UHFFFAOYSA-N
CAS DataBase Reference
123-31-9(CAS DataBase Reference)
NIST Chemistry Reference
Hydroquinone(123-31-9)
EPA Substance Registry System
1,4-Benzenediol(123-31-9)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Hazard Codes  Xn,N
Risk Statements  22-40-41-43-50-68-R68-R50-R43-R41-R40-R22
Safety Statements  26-36/37/39-61-S61-S36/37/39-S26
RIDADR  2662
WGK Germany  3
RTECS  MX3500000
Autoignition Temperature 930 °F
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29072210
Hazardous Substances Data 123-31-9(Hazardous Substances Data)
Toxicity LD50 orally in rats: 320 mg/kg (Woodard)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P501 Dispose of contents/container to..…

NFPA 704

Diamond Hazard Value Description
1
2 0
Health   2 Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
Flammability   1 Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
Instability   0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
Special  

(NFPA, 2010)

Hydroquinone price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 74347 Hydroquinone certified reference material, TraceCERT 123-31-9 100mg $88.5 2018-11-13 Buy
Sigma-Aldrich 1324002 Hydroquinone United States Pharmacopeia (USP) Reference Standard 123-31-9 500mg $348 2018-11-13 Buy
TCI Chemical H0186 Hydroquinone >99.0%(T) 123-31-9 25g $16 2018-11-22 Buy
TCI Chemical H0186 Hydroquinone >99.0%(T) 123-31-9 500g $32 2018-11-22 Buy
Alfa Aesar A11411 Hydroquinone, 99% 123-31-9 250g $20.6 2018-11-13 Buy

Hydroquinone Chemical Properties,Uses,Production

Chemical Properties

white needle-like crystals or crystalline powder

Chemical Properties

Hydroquinone, a colorless, hexagonal prism, has been reported to be a good antimitotic and tumor-inhibiting agent. It is a reducing agent used in a photographic developer, which polymerizes in the presence of oxidizing agents. In the manufacturing industry it may occur include bacteriostatic agent, drug, fur processing, motor fuel, paint, organic chemicals, plastics, stone coating, and styrene monomers.

Uses

hydroquinone is a pigment-lightening agent used in bleaching creams. Hydroquinone combines with oxygen very rapidly and becomes brown when exposed to air. Although it occurs naturally, the synthetic version is the one commonly used in cosmetics. Application to the skin may cause allergic reaction and increase skin sun sensitivity. Hydroquinone is potentially carcinogenic and is associated with causing ochronosis, a discoloration of the skin. The u.S. FDA has banned hydroquinone from oTC cosmetic formulations, but allows 4 percent in prescription products. Its use in cosmetics is prohibited in some european countries and in Australia.

Uses

As photographic reducer and developer; as reagent in the determination of small quantities of phosphate; as antioxidant.

Uses

Use as photographic reducer and developer; as reagent in the determination of small quantities of phosphate; as antioxidant. Depigmentor

Uses

K channel agonist, antihypertensive

Uses

hydroquinone is a pigment-lightening agent used in bleaching creams. Hydroquinone combines with oxygen very rapidly and becomes brown when exposed to air. Although it occurs naturally, the synthetic version is the one commonly used in cosmetics. Application to the skin may cause allergic reaction and increase skin sun sensitivity. Hydroquinone is potentially carcinogenic and is associated with causing ochronosis, a discoloration of the skin. The u.S. FDA has banned hydroquinone from oTC cosmetic formulations, but allows 4 percent in prescription products. Its use in cosmetics is prohibited in some european countries and in Australia.

Uses

reducing agent prevents polymerization of resin monomers lightens darkened skin, light sensitive

Definition

ChEBI: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.

brand name

Aida;Ambi- skin tone;Black and white;Creme des 3 fleur d'orient;Eldopaque forte;Eldoquin forte 4% cream;Epocler;Esoterica facial;Esoterica regular;Esoterica sensitive skin;Esoterica sunscreen;Melanex topical sollution;Melpaque hp;Melqui hp;Neostrata aha gel;Neostrata hq;Nuquin hp;Pigmanorm;Porcelana;Sinquin;Solaquin forte sun bleaching;Superfade age spot;Ultraquin plaine.

World Health Organization (WHO)

Hydroquinone was introduced in 1965 as a topical depigmenting agent for hyperpigmentation. At high concentrations hydroquinone is corrosive and in most countries has been restricted to the level of approximately 2% and limited to the period of less than 2 months. Additional consideration for restrictive action is that animal experiments have also demonstrated carcinogenic and mutagenic potential of hydroquinone.

General Description

Light colored crystals or solutions. May irritate the skin, eyes and mucous membranes. Mildly toxic by ingestion or skin absorption.

Air & Water Reactions

Darkens on exposure to air and light. Miscible in water. Solutions become brown in air due to oxidation. Oxidation is very rapid in the presence of alkali.

Reactivity Profile

Hydroquinone is a slight explosion hazard when exposed to heat. Incompatible with strong oxidizing agents. Also incompatible with bases. Hydroquinone reacts with oxygen and sodium hydroxide. Reacts with ferric salts . Hot and/or concentrated NaOH can cause Hydroquinone to decompose exothermically at elevated temperature. (NFPA Pub. 491M, 1975, 385)

Hazard

Toxic by ingestion and inhalation, irritant. Questionable carcinogen.

Health Hazard

Exposures to hydroquinone in large quantities by accidental oral ingestion produce toxicity and poisoning. The symptoms of poisoning include, but are not limited to, blurred speech, tinnitus, tremors, sense of suffocation, vomiting, muscular twitching, headache, convul- sions, dyspnea and cyanosis from methemoglobinemia, coma, and collapse from respira- tory failure. Occupational workers should be allowed to work with protective clothing and dust masks with full-face or goggles to protect the eyes, and under proper management.

Health Hazard

Hydroquinone is very toxic; the probable oral lethal dose for humans is 50-500 mg/kg, or between 1 teaspoon and 1 ounce for a 150 lb. person. It is irritating but not corrosive. Fatal human doses have ranged from 5-12 grams, but 300-500 mg have been ingested daily for 3-5 months without ill effects. Death is apparently initiated by respiratory failure or anoxia.

Fire Hazard

Dust cloud may explode if ignited in an enclosed area. Hydroquinone can react with oxidizing materials and is rapidly oxidized in the presence of alkaline materials. Oxidizes in air.

Contact allergens

Hydroquinone is used in photography developers (black and white, X-ray, and microfilms), in plastics, in hair dyes as an antioxidant and hair colorant. Hydroquinone is found in many skin bleaching creams.

Purification Methods

Crystallise quinol from acetone, *benzene, EtOH, EtOH/*benzene, water or acetonitrile (25g in 30mL), preferably under nitrogen. Dry it under vacuum. [Wolfenden et al. J Am Chem Soc 109 463 1987, Beilstein 6 H 836, 6 IV 5712.]

Hydroquinone Preparation Products And Raw materials

Raw materials

Preparation Products


Hydroquinone Suppliers

Global( 438)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1730 55
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 sales@crovellbio.com CHINA 407 50
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21990 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 fandachem@gmail.com CHINA 2553 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-89880739
022-66880086 sales@tjzxchem.com CHINA 558 58
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 615 58

View Lastest Price from Hydroquinone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-09 Hydroquinone
123-31-9
US $2.00 / KG 1KG 99% Customise career henan chemical co
2019-04-28 Hydroquinone
123-31-9
US $10.00 / kg 1kg 99% 500tons/month Hebei Chisure Biotechnology Co., Ltd.
2019-04-01 lidocaine hydrochloride
123-31-9
US $1.00 / kg 100g 99.9% 10tons Hebei Jimi Trading Co., Ltd.

Hydroquinone Spectrum


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