ChemicalBook CAS DataBase List 5-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid

5-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid synthesis

6synthesis methods

Product Name:5-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid
CAS Number:1219-33-6
Molecular formula:C13H10O5
Molecular Weight:246.22

5-(benzyloxy)-2-(hydroxymethyl)-4H-pyran-4-one

15771-06-9

1219-33-6

5-Benzyloxy-4-oxo-4H-pyran-2-carboxylic acid was synthesized in the following steps: first, 90 g of tricarboxylic acid was added to a 2000 ml round-bottomed flask, and 660 ml of methanol was added to dissolve the tricarboxylic acid. Subsequently, 88 g of benzyl chloride and 63 ml of 40% sodium hydroxide solution were added, and the reaction was heated and refluxed for 17 h to obtain reaction solution a. After the reaction was completed, reaction solution a was distilled under reduced pressure until the solvent was completely evaporated to obtain a dry residue. After the residue was cooled to room temperature, 60 ml of methanol and 240 ml of water were added, stirred and mixed, then washed and filtered, and 116 g of light yellow solid intermediate was obtained after drying. 116 g of the intermediate was added to a reactor with 2000 ml of water and the reaction system was cooled to -5°C. Under temperature control not exceeding 5°C, sodium periodate was added, followed by dropwise addition of 40 ml of water. After the dropwise addition, the reaction was stirred for 10 minutes, then the reaction temperature was raised to 17°C and stirring was continued for 3 hours. After completion of the reaction, the reaction solution was filtered and the filtrate was adjusted to pH 5-6 with hydrochloric acid. 500 g of ethyl acetate was used to extract the filtrate and separate the organic and aqueous phases. The organic phase was dried and filtered, and the solid obtained was dried to give a final 80 g of white solid, which was the target product 5-benzyloxy-4-oxo-4H-pyran-2-carboxylic acid.

15771-06-9
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5-(benzyloxy)-4-oxo-4H-pyran-2-carbaldehyde

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1219-33-6
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Yield: 38% ， 6 %Chromat.

Reaction Conditions:

with potassium bromate;sodium hypochlorite;2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;tetrabutylammomium bromide;sodium hydrogencarbonate in dichloromethane;water at 0; for 0.1 - 0.15 h;Product distribution / selectivity;

Steps:

2.1; A.a
EXAMPLE 2 Preparation of 5-benzyloxy-4-oxo-4H-pyran-2-carbaldehyde Method 1-TEMPO oxidation: Solid NaHCO₃ (96.0 g, 1.21 mol) and deionized water (125 mL) were added to a mixture of 5-benzyloxy-2-hydroxymethyl-pyran-4-one (40.0 g, 0.17 mol) in CH₂Cl₂ (550 mL) and deionized water (200 mL). The mixture was cooled in an ice-salt bath to about 0° C. Then, KBrO₃ (4.00 g, 24.1 mmol), n-Bu₄N⁺Br^- (2.20 g, 6.90 mmol) and TEMPO (0.54 g, 3.44 mmol) were successively added. To the resulting heterogeneous mixture at 0° C. was added a solution of 1.59 M NaOCl (140 mL, 1.3 equiv) within 5-7 min. The reaction mixture turned to orange then to bright yellow during the NaOCl addition. The mixture was stirred for an additional 1-2 min, and then the solid was filtered off by suction filtration. The filtrate was placed in a separatory funnel, and the organic fraction was collected and dried over sodium sulfate. Analysis of the crude mixture by HPLC Method 1 (λ=280 nm), as described above, indicated the presence of the over-oxidized product (5-benzyloxy-4-oxo-4H-pyran-2-carboxylic acid, peak percent area: 6%, RT=9.42 min), the desired product (5-benzyloxy-4-oxo-4H-pyran-2-carbaldehyde, peak percent area is 85%, and its RT is 11.34 min) and the starting material (5-benzyloxy-2-hydroxymethyl-pyran-4-one, peak percent area is 8%, and its RT is 12.18 min). The organic fraction was filtered and the volume was reduced to about 60 mL using the rotary evaporator. The mixture was placed on top of a wet-packed silica gel column, and eluted with ethyl acetate. The fractions containing the product were combined. Upon concentration on the rotary evaporator (volume reduction), the product separated out as a solid. The solid was collected by suction filtration to provide a first crop (10 g after drying under vacuum). The filtrate was collected and the volume of solvent reduced under vacuum. The precipitated solid was collected by filtration to give a second crop (5 g after drying under vacuum). The crops were combined to provide a 38% yield of the titled compound. The purity (peak area percent is 97.4%) of this material was analyzed by HPLC Method 1 as described above. ¹H NMR (400 MHz, DMSO-D₆) δ (ppm): 9.64 (s, 1H), 8.41 (s, 1H), 7.32-7.43 (m, 5H), 7.13 (s, 1H), 5.01 (s, 2H, CH₂Ph).

References:

Apotex Technologies Inc. US2008/242706, 2008, A1 Location in patent:Page/Page column 12; 19; 39

15771-06-9
59 suppliers
$25.00/250mg

1219-33-6
57 suppliers
$72.00/100mg

References

501-30-4 Synthesis