5-Benzylthio-1H-tetrazole synthesis
- Product Name:5-Benzylthio-1H-tetrazole
- CAS Number:21871-47-6
- Molecular formula:C8H8N4S
- Molecular Weight:192.24
3012-37-1
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21871-47-6
240 suppliers
$27.00/1g
Yield:21871-47-6 93%
Reaction Conditions:
with Caswell No. 744A;L-proline in propyl alcohol;Resolution of racemate;Green chemistry;
Steps:
General procedure for the synthesis of 5-(substituted sulfanyl)- 1H-tetrazoles 5
General procedure: The mixture of appropriate thiocyanate (1 mmol), NaN3 (1.25 mmol) and L-proline (30 mol%) inn-PrOH (5 mL) was refluxed for 1-2 h. The progress of the reaction was monitored by TLC.After completion of the reaction, the reaction mixture was allowed to cool to room temperature.The cooled reaction mixture was poured in ice water (15 mL) with stirring. The resulting mixturewas acidified with dilute HCl under vigorous stirring. The solid product was filtered undersuction, washed with sufficient cold water. The solid was air dried to obtain the pure product.*For organic thicyanates, n-propanol was used as a solvent instead of DMF for better results.
References:
Bhagat, Saket B.;Telvekar, Vikas N. [Synlett,2018,vol. 29,# 7,art. no. ST-2017-B0838-L,p. 874 - 879] Location in patent:supporting information
100-44-7
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79-19-6
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21871-47-6
240 suppliers
$27.00/1g
57216-15-6
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21871-47-6
240 suppliers
$27.00/1g