5-BroMo-1-isopropylbenzoiMidazole synthesis
- Product Name:5-BroMo-1-isopropylbenzoiMidazole
- CAS Number:1200114-01-7
- Molecular formula:C10H11BrN2
- Molecular Weight:239.11
1092292-39-1
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Yield:-
Reaction Conditions:
with hydrogenchloride in water;N,N-dimethyl-formamide at 100; for 8 h;
Steps:
271 Example 271
[0001005] To a solution of Compound 271C (1.3 g, 5.70 mmol) in DMF (30 mL) was added triethoxymethane (4.74 mL, 28.5 mmol) and con. HC1 (1.5 mL). The mixture was stirred at 100 °C for 8 h. After cooling down to room temperature, the mixture was poured into water (150 mL) and adjusted to pH 8 with saturated aqueous sodium bicarbonate solution (3.5 mL). The mixture was extracted with ethyl acetate (50 mL x 3) and separated. The combined organic phases were washed with water (10 mL x 2) and brine (10 mL), dried over anhydrous sodium sulfate, filtered, and concentrated. The crude product was purified with flash column chromatography on silica gel (ethyl acetate in petroleum ether, from 0% to 50% v/v) to yield Compound 271D.
References:
WO2015/42397,2015,A1 Location in patent:Paragraph 0001005
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1200114-01-7
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