5-BROMO-2-(1H-PYRROL-1-YL)PYRIMIDINE synthesis
- Product Name:5-BROMO-2-(1H-PYRROL-1-YL)PYRIMIDINE
- CAS Number:478258-70-7
- Molecular formula:C8H6BrN3
- Molecular Weight:224.06
109-97-7
357 suppliers
$9.00/5G
62802-38-4
197 suppliers
$10.00/1g
478258-70-7
23 suppliers
$95.43/1gm:
Yield:478258-70-7 46%
Reaction Conditions:
with potassium carbonate in dimethyl sulfoxide at 70; for 24 h;Schlenk technique;
Steps:
Preparation of Substrates; General Procedure
General procedure: 5-Bromo-2-fluoropyridine (0.5 mmol), an N-heterocyclic amine (1.0 mmol) and K2CO3 (1.0 mmol) were added to a 25-mL Schlenk tube, followed by addition of DMSO (2 mL). The reaction mixture was heated to 70 °C for 24 h under air atmosphere. Then, the reaction mixture was added to brine (15 mL) and this mixture was extracted with CH2Cl2 (3 × 15 mL). The combined extracts were concentrated under reduced pressure and the product was isolated by flash chromatography on a silica gel (200-300 mesh) column.
References:
Tao, Sheng;Ji, Enhui;Shi, Lei;Liu, Ning;Xu, Liang;Dai, Bin [Synthesis,2017,vol. 49,# 23,p. 5120 - 5130]
109-97-7
357 suppliers
$9.00/5G
183438-24-6
398 suppliers
$6.00/1g
478258-70-7
23 suppliers
$95.43/1gm:
696-59-3
402 suppliers
$7.00/25g
7752-82-1
442 suppliers
$13.00/25g
478258-70-7
23 suppliers
$95.43/1gm:
109-97-7
357 suppliers
$9.00/5G
32779-36-5
654 suppliers
$5.00/5g
478258-70-7
23 suppliers
$95.43/1gm: