5-Bromo-2-fluorobenzylamine hydrochloride synthesis
- Product Name:5-Bromo-2-fluorobenzylamine hydrochloride
- CAS Number:99725-13-0
- Molecular formula:C7H6BrFO
- Molecular Weight:205.02
93777-26-5
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99725-13-0
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Yield: 100%
Reaction Conditions:
Stage #1:5-bromo-2-fluorobenzaldehyde with sodium tetrahydroborate;ethanol at 0 - 20; for 15 h;Inert atmosphere;
Stage #2: with water;ammonium chloride in ethanol at 0;
Steps:
4
Preparation Example 4(5-Bromo-2-fluorophenyl)methanolTo a solution of 5-bromo-2-fluorobenzaldehyde (30.0 g, 148 mmol) in EtOH was added sodium borohydride (8.39 g, 222 mmol) at 0 °C. The resulting mixture was stirred with gradual warming to ambient temperature over 15 h, re-cooled to 0 °C, and quenched with aq. saturated NH4C1 solution. The mixture was extracted with EtOAc. The organic layer was washed with brine, dried over MgS04, filtered and evaporated in vacuo to yield the titled compound (30.3 g, quantitative) as a white sold, which was carried on to the next step without further purification.[M-OH"]+ 187.
References:
GREEN CROSS CORPORATION;LEE, Jinhwa;KIM, Jeongmin;LEE, Suk Ho;LEE, Junwon;SONG, Kwang-Seop;PARK, Eun-Jung;KIM, Min Ju;SEO, Hee Jeong;LEE, Sung-Han;SON, Eun Jung;KIM, Jong Yup;KANG, Suk Youn;KONG, Younggyu WO2011/159067, 2011, A2 Location in patent:Page/Page column 51
67-56-1
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93777-26-5
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$5.00/5g
99725-13-0
124 suppliers
$7.00/250mg
146328-85-0
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99725-13-0
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99748-26-2
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99725-13-0
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51437-00-4
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99725-13-0
124 suppliers
$7.00/250mg