5-BROMO-2H-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-ONE synthesis
- Product Name:5-BROMO-2H-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-ONE
- CAS Number:864933-07-3
- Molecular formula:C6H4BrN3O
- Molecular Weight:214.02
Yield:864933-07-3 64%
Reaction Conditions:
in tetrahydrofuran; for 1 h;
Steps:
2 5-bromo-ri.2.41triazolor4.3-alpyridin-3(2HVone (2-3 )
To a solution of 2-2 (1.1 g, 5.85 mmol) in THF (50 mL) was added carbonyldiimidazole (1.14 g, 7.02 mmol), and the mixture was stirred for 1 h. The reaction was diluted with water (150 mL) and EtOAc (150 mL), causing a precipitate to form. The mixture was filtered through a sintered glass filter, yielding 0.8 g (64%) of 2-3 as a tan solid. 1H NMR (300 MHz, CHCl3-i δ 9.34 (s, 1 H), 7.03 (m, 1 H), 6.85 (m, 1 H), 6.59 (m, 1 H).
References:
WO2013/74390,2013,A1 Location in patent:Page/Page column 36; 37
144100-07-2
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864933-07-3
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