Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>1,1'-Carbonyldiimidazole

1,1'-Carbonyldiimidazole

1,1'-Carbonyldiimidazole Structure
1,1'-Carbonyldiimidazole structure
CAS No.
530-62-1
Chemical Name:
1,1'-Carbonyldiimidazole
Synonyms
CDI;CARBONYLDIIMIDAZOLE;1,1'-CARBONYLDIIMIDAZOLE (CDI);DI(1H-IMIDAZOL-1-YL)METHANONE;N,N-CARBONYLDIIMIDAZOLE;Diimidazolyl ketone;1,1-CARBONYL DIIMIDAZOLE;5% Pd-BaSO4;CARBODIIMIDAZOLE;Di-imidazol-1-yl-methanone
CBNumber:
CB0215374
Molecular Formula:
C7H6N4O
Molecular Weight:
162.15
MDL Number:
MFCD00005286
MOL File:
530-62-1.mol
MSDS File:
SDS
Last updated:2025-10-21 20:59:21
Product description Number Pack Size Price
CDI 1,1′-Carbonyldiimidazole Novabiochem? 8.51054 25g $88.5
1,1′-Carbonyldiimidazole for synthesis 8.02301 2G $33.8
CDI 1,1′-Carbonyldiimidazole Novabiochem? 8.51054 100g $264
CDI 1,1′-Carbonyldiimidazole Novabiochem® 8.51054 1 kg $956
CDI 1,1′-Carbonyldiimidazole Novabiochem® 8.51054 1 kg $956
More product size
Request For Quotation

1,1'-Carbonyldiimidazole Properties

Melting point 117-122 °C(lit.)
Boiling point 288.83°C (rough estimate)
Density 1.303 g/mL at 25 °C
vapor pressure 0.006-0.012Pa at 20-25℃
refractive index n20/D1.434
storage temp. 2-8°C
solubility Soluble in dimethylformamide.
form Crystalline Powder
pka 2.90±0.10(Predicted)
color White to light cream
PH Range 7.7 at 50 g/l
PH 7.7 (50g/l, H2O, 20℃)
Water Solubility Insoluble in water
Sensitive Moisture Sensitive
Merck 14,1819
BRN 6826
Stability Stable, but moisture-sensitive. Incompatible with acids, strong oxidizing agents, water.
InChIKey PFKFTWBEEFSNDU-UHFFFAOYSA-N
CAS DataBase Reference 530-62-1(CAS DataBase Reference)
FDA UNII 63A10X1FSP
EPA Substance Registry System 1H-Imidazole, 1,1'-carbonylbis- (530-62-1)
UNSPSC Code 12352115
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H314-H360D
Precautionary statements  P260-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  C,Xi,Xn
Risk Statements  22-34-36/37/38-40-36/38
Safety Statements  26-36/37/39-45-37/39-27-36/37
RIDADR  UN 3263 8/PG 2
WGK Germany  2
F  10-21
Hazard Note  Harmful/Corrosive/Moisture Sensitive
TSCA  T
HazardClass  8
PackingGroup  III
HS Code  29332990
Toxicity LD50 orally in Rabbit: 1071 mg/kg
Limited Quantities 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
1
3 1

1,1'-Carbonyldiimidazole price More Price(74)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.51054 CDI 1,1′-Carbonyldiimidazole Novabiochem? 530-62-1 25g $88.5 2025-07-31 Buy
Sigma-Aldrich 8.02301 1,1′-Carbonyldiimidazole for synthesis 530-62-1 2G $33.8 2025-07-31 Buy
Sigma-Aldrich 8.51054 CDI 1,1′-Carbonyldiimidazole Novabiochem? 530-62-1 100g $264 2025-07-31 Buy
Sigma-Aldrich 8.51054 CDI 1,1′-Carbonyldiimidazole Novabiochem® 530-62-1 1 kg $956 2025-07-31 Buy
Sigma-Aldrich 8.51054 CDI 1,1′-Carbonyldiimidazole Novabiochem® 530-62-1 1 kg $956 2025-07-31 Buy
Product number Packaging Price Buy
8.51054 25g $88.5 Buy
8.02301 2G $33.8 Buy
8.51054 100g $264 Buy
8.51054 1 kg $956 Buy
8.51054 1 kg $956 Buy

1,1'-Carbonyldiimidazole Chemical Properties,Uses,Production

Chemical Properties

The substance appears as a white to slightly pale-yellow crystalline powder with a melting point range of 115.5-116°C. It exhibits poor solubility in water, while displaying solubility in alcohol and ether.

Application

Peptide coupling reagent1,1'-Carbonyldiimidazole acts as a coupling reagent and utilized for coupling of amino acids in order to prepare peptide in organic synthesis. It is also used in the preparation of beta-keto sulfones, sulfoxides and beta-enamino acid derivatives. It is used to convert alcohols and amines into carbamates, esters, and ureas. It is involved in the preparation of formylized imidazole by reaction with formic acid. Further, it is used in the synthesis of dipolar polyamides compounds. In addition to this, it is considered as an equivalent of phosgene and used to prepare asymmetric bis alkyl carbonate.

Uses

CDI, also known as 1,1'-carbonyldiimidazole, is a commonly used peptide coupling reagent in the synthesis of peptides and nucleoside triphosphates. It usually contains approximately 10% imidazole and reacts rapidly with carboxylic acids to produce acyl imidazoles. Later, it readily reacts with amines to create amides. In addition, CDI is useful in converting alcohols and amines into a range of chemical compounds, including carbamates, esters, and ureas.

Preparation

1,1'-Carbonyldiimidazole has been prepared by the reaction of imidazole and phosgene in anhydrous benzene and anhydrous tetrahydrofuran. It has also been obtained by the reaction of 1-(trimethylsilyl)imidazole and phosgene in anhydrous benzene, but that method offers no advantages that justify the more extensive preparative effort required.
DOI: 10.15227/orgsyn.048.0044

General Description

1,1′-Carbonyldiimidazole (N,N′-carbonyldiimidazole) is a versatile peptide-forming reagent.

reaction suitability

reaction type: Coupling Reactions

Purification Methods

Crystallise it from *benzene or tetrahydrofuran in a dry-box and store it dry. [Hearn Methods Enzymol 135 102 1987, Beilstein 23/4 V 245.]

Precautions

1,1'-Carbonyldiimidazole is incompatible with oxidizing agents and strong acids and should not be stored or handled near them. Store in a refrigerator, under inert gas and protected from moisture. This substance is heat sensitive and moisture sensitive.

References

[1] Journal of Nanoscience and Nanotechnology, 2018, vol. 18, # 1, p. 234 - 241

1,1'-Carbonyldiimidazole synthesis

32315-10-9
18156-74-6
530-62-1
Synthesis of 1,1'-Carbonyldiimidazole from Triphosgene and N-(Trimethylsilyl)imidazole

1,1'-Carbonyldiimidazole Preparation Products And Raw materials

Raw materials

Imidazole N-(Trimethylsilyl)imidazole PHOSGENE Benzene N,N-Dimethylformamide
Diphosgene

1of2

Preparation Products

2-(Boc-aminomethyl)-piperidine 3-oxo-3-phenyl-propanamide 5-(Pyridin-3-yl)-1H-pyrazole-3-carboxamide ,97% 3-Cyanomethylthiophene 4-AMINOMETHYL-BENZAMIDE
2,8-DICHLOROPYRIMIDO[5,4-D]PYRIMIDINE Progabide 2-AMINO-5-BROMOBENZAMIDE 2-Ethylpiperazine 6-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONITRILE
Pazufloxacin 5-BROMOTHIOPHENE-2-CARBONITRILE N-Heptafluorobutyrylimidazole 4-(Boc-Aminomethyl)piperidine 8-METHOXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID AMIDE
2-chloro-5-cyanopyridine 7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID AMIDE 1-Boc-2-Methylpiperazine 3-(1H-INDOL-3-YL)-1-PROPANAMINE 1-(4-ACETYLPIPERIDINO)ETHAN-1-ONE
5-BROMO-2-BENZOXAZOLINONE 97 isoglutamine 3-BROMOTHIOPHENE-2-CARBOXAMIDE 1-Boc-4-(aminomethyl)piperidine 2,3-diaminonaphthalene
4-N-BOC-Aminopiperidine 5-AMINO-3-PYRIDINECARBONITRILE 4-Cyanopiperidine 1,3-THIAZOLIDIN-2-ONE

1of6

1,1'-Carbonyldiimidazole Suppliers

Global( 1167)Suppliers
Supplier Tel Email Country ProdList Advantage
Suzhou Highfine Biotech Co.,Ltd. 		+86-0512-68071238 +86-13771819922 june@highfine.com China 458 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 24727 58
Shandong Believe Chemical PTE.LTD
+86-18553607090 +8618553607090 1093908296@qq.com China 1663 58
CD Chemical Group Limited
+8615986615575 info@codchem.com China 20342 58
Jinan Dexinjia Bio&Tech Co., Ltd
+86-0531-82375818 +86-15064153060 sales@jndxj.com China 1371 58
Shanghai Likang New Materials Co., Limited
+86-16631818819 +86-17736933208 3684455296@qq.com China 9300 58
.GZ HONESTCHEM CO.,LTD 		+8615013270415 honestchemical@foxmail.com China 285 58
Sichuan Zhuoyu Yantang Technology Co., Ltd. 		+8613288715578 sales@sichuanzyyt.com China 12217 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5250 58
Shaanxi Didu New Materials Co. Ltd 		+86-89586680 +86-13289823923 1026@dideu.com China 9080 58
Supplier Advantage
Suzhou Highfine Biotech Co.,Ltd. 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Shandong Believe Chemical PTE.LTD
58
CD Chemical Group Limited
58
Jinan Dexinjia Bio&Tech Co., Ltd
58
Shanghai Likang New Materials Co., Limited
58
.GZ HONESTCHEM CO.,LTD 		58
Sichuan Zhuoyu Yantang Technology Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Shaanxi Didu New Materials Co. Ltd 		58

Related articles

  • What is 1,1'-Carbonyldiimidazole?
  • 1,1'-Carbonyldiimidazole (CDI) is an organic compound with the molecular formula (C3H3N2) 2CO. It is a white crystalline solid....
  • Jan 2，2020

View Lastest Price from 1,1'-Carbonyldiimidazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,1'-Carbonyldiimidazole pictures 2025-11-17 1,1'-Carbonyldiimidazole
530-62-1
 US $0.00 / G/KG 1G/KG 99% 10000000KG Anhuyan (Hainan) Biotechnology Co., LTD
1,1'-Carbonyldiimidazole pictures 2025-11-17 1,1'-Carbonyldiimidazole
530-62-1
 US $5.00 / kg 1kg 99% 200mt Jinan Finer Chemical Co., Ltd
1,1'-Carbonyldiimidazole pictures 2025-11-17 1,1'-Carbonyldiimidazole
530-62-1
 US $1000.00-400.00 / kg 1kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

1,1'-Carbonyldiimidazole Spectrum

1,1'-Carbonyldiimidazole(530-62-1)MS1,1'-Carbonyldiimidazole(530-62-1)1HNMR1,1'-Carbonyldiimidazole(530-62-1)13CNMR1,1'-Carbonyldiimidazole(530-62-1)IR11,1'-Carbonyldiimidazole(530-62-1)Raman

530-62-1(1,1'-Carbonyldiimidazole)Related Search:

Cobalt carbonyl DIIRON NONACARBONYL Imidocarb dipropionate 1-Methylimidazole Imidazole
cis-Octahydro-1H-isoindole hydrochloride Pentamethyldiethylenetriamine N-(2-Hydroxyethyl)pyrrolidine Morpholine Magnesium chloride
Boric acid Benzamidine hydrochloride Chromium nicotinate Terbinafine Dicaprylyl carbonate
Ethylene thiourea Pyridoxamine dihydrochloride Nucleoside

1of4

LABOTEST-BB LT00233203 IM2 C O (DIIMIDAZOL-1-YL)KETONE AKOS BBS-00004316 RARECHEM AK HZ 0060 1.1'-CARBONYL-BIS-IMIDAZOLE 1H-IMIDAZOLE, 1,1'-CARBONYLBIS- 1,1’-carbonylbis-1h-imidazol 1,1’-Carbonyldiimidazol 1,1'-Carbonylbis-1H-imidazole [Coupling Agent for Peptides Synthesis] 1,1'-Carbonyldiimidazole [Coupling Agent for Peptides Synthesis] 1,1'-Carbonyldi(1H-imidazole) Bis(1H-imidazol-1-yl) ketone Bis(1-imidazolyl) ketone carbonyl-1,1’-bis-1H-diimidazole 1,1'-Carbonyldiimidazole,97% 1’-Carbonyldiimidazole 1,1'-Carbonyldiimida 1,1'-CarbonyldiiMidazole, >90% N'-CarbonyldiiMidazole (CDI) Product 2: N,N'-CarbonyldiiMidazole N,Nzzhlxy-Carbonyldiimidazole (CDI) CDI (Carbonyl Diimidazole) CARBONYLDIIMIDAZOLE N,N CDI (N,N'-Carbonyldiimidazole) 1,1-Carbonyldiimidazole99% N,N'-Carbonyldiimidazole, 98%+ N,N'-Carbonyl diimidazole (CDI) N,N'-Carbonyldiimidazole,97% N,N'-CARBONYL-BIS-(IMIDAZOLE) N,NCARBONYLDIIMIDAZOLE,HIGHPURITY N,N'-Carbonyldiimidazole 98% 1,1''-CARBONYLDIIMIDZOLE CDI 1,1''-CARBONYLDIIMIDAZOLE N.N''-CARBONYL DICMIDAZOLE 1H-Imidazole,1,1-carbonylbis-(9CI) Bis(iMidazol-1-yl) Ketone Bis(iMidazol-1-yl)Methanone NSC 67203 1,1-CarbonyldiMidazole 1,1'-Carbonylbis-1H-imidazole CDI 1,1'-CarbonyldiiMdazole 1,1''-CARBONYLDIIMIDAZOLE FOR SYNTHESIS CarbonyldiiMaidiazole n,ni-carbonyldiimidazole CDI >=97.0% (T) CDI reagent grade 1,1′-Carbonyldiimidazole solution CDI Vetec(TM) reagent grade, 97% Methanone, di-1H-imidazol-1-yl- N,N-Carbonyldiimidazole≥ 98% (Titration) N,N-Carbonyldiimidazole Manufacturer N’N-Carbonyldiimidazole, CAS No. (Used in manufacture of Ramipril and other drugs) 97.0%(W) 1,1'-Carbonyldiimidazole [Coupling Agent for Peptides Synthesis]> 1,1'-Carbonyldiimidazole, > CDI 1,1'-Carbonyldiimidazole,98% 1,1'-CarbonyL