ChemicalBook CAS DataBase List 5-bromo-8-methoxyquinoline(SALTDATA: HCl)

5-bromo-8-methoxyquinoline(SALTDATA: HCl) synthesis

12synthesis methods

Product Name:5-bromo-8-methoxyquinoline(SALTDATA: HCl)
CAS Number:10522-47-1
Molecular formula:C10H8BrNO
Molecular Weight:238.08

938-33-0
101 suppliers
$22.80/250mg

5-bromo-8-methoxyquinoline(SALTDATA: HCl)

10522-47-1
45 suppliers
$31.00/200μmol

Yield:10522-47-1 92%

Reaction Conditions:

with bromine in chloroform at 20; for 48 h;Darkness;

Steps:

2.2.1. Genaral Procedure for Bromination of 8-substituted Quinolines (2-4)

General procedure: To synthesize brominated 8-substituted quinolines (5-10) experimental procedures were repeated in literature [19]. In brief, to a solution of 8-substituted quinoline 2-4 (2 mmol, 1 eq) in distilled CHCl3 (15 mL) was added a solution of molecular bromine (different eqivalents) in CHCl3 over 10 min in the dark at ambient temperature and stirred for 2 days. The reaction was monitored by TLC; after completion of the reaction, the organic layer was washed with 5% NaHCO3 (3 × 20 mL), dried over Na2SO4, and concentrated under reduced pressure. The products was isolated by alumina column, eluting with AcOEt/hexane (1:5, 150 mL).

References:

?kten, Salih;?akmak, Osman;Tekin, ?aban;K?prülü, Tu?ba Kul [Letters in drug design and discovery,2017,vol. 14,# 12,p. 1415 - 1424]