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ChemicalBook CAS DataBase List 5-BROMOMETHYL-1,2,3-TRIMETHOXY-BENZENE
21852-50-6

5-BROMOMETHYL-1,2,3-TRIMETHOXY-BENZENE synthesis

10synthesis methods
3,4,5-Trimethoxybenzyl alcohol

3840-31-1

5-BROMOMETHYL-1,2,3-TRIMETHOXY-BENZENE

21852-50-6

General method: 3,4,5-trimethoxybenzyl alcohol (1 mmol) was dissolved in anhydrous benzene (15 mL), phosphorus tribromide (0.5 mL) was added and the reaction was stirred at room temperature. Upon completion of the reaction, 3,4,5-trimethoxybenzyl bromide was obtained in quantitative yield by a conventional post-treatment step.

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Yield: 100%

Reaction Conditions:

with phosphorus tribromide in benzene at 20;

Steps:

Step-II (Preparation of benzyl bromides)
General procedure: benzyl alcohols (1 mmol) in dry benzene (15 mL) and phosphorus tribromides (0.5 mL) and stirred at room temperature to get respective benzyl bromides in quantitative yields, usual work-up.

References:

Parihar, Swati;Kumar, Amit;Chaturvedi, Amit K.;Sachan, Naresh Kumar;Luqman, Suaib;Changkija, Bendangla;Manohar, Murli;Prakash, Om;Chanda;Khan, Feroz;Chanotiya;Shanker, Karuna;Dwivedi, Anila;Konwar, Rituraj;Negi, Arvind S. [Journal of Steroid Biochemistry and Molecular Biology,2013,vol. 137,p. 332 - 344]

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