5-CHLORO-3-METHYL-1-PHENYLPYRAZOLE synthesis
- Product Name:5-CHLORO-3-METHYL-1-PHENYLPYRAZOLE
- CAS Number:1131-17-5
- Molecular formula:C10H9ClN2
- Molecular Weight:192.64
89-25-8
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1131-17-5
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Yield: 90.5%
Reaction Conditions:
with trichlorophosphate at 60 - 110; for 3 h;
Steps:
1 Compound B preparation process
In a dry four-necked flask, 184 g of phosphorus oxychloride was added.Then 172 g of compound C (3-methyl-1-phenyl-5-pyrazolone) was added,After stirring and stirring for 30 minutes, the temperature is raised to 60°C.Then let it naturally warm up to 80°C,Stay for 30 minutes,No longer warming upReheat to 110°C for 2 hours,Pour the material into 1500 ml waterIn the separatory funnel, separate the lower oil,3X100ml washed three times, the oil was vacuum distilled 3mm mercury 100-110 ° C to give 3-methyl-1-phenyl-5-chloropyrazole dry product 174 g,Content 99.5% (yield 90.5%).
References:
Jiangxi Kaiyuan Bio-pharmaceutical Technology Co., Ltd.;Xiangtan Kaiyuan Chemical Co., Ltd.;Chen Luwu;Zhou Zhijun CN107935933, 2018, A Location in patent:Paragraph 0033; 0034; 0035; 0036
1131-18-6
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1131-17-5
102 suppliers
$45.00/50mg
60-80-0
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1131-17-5
102 suppliers
$45.00/50mg
56159-67-2
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1131-17-5
102 suppliers
$45.00/50mg
