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Antipyrine

Antipyrine
Antipyrine structure
CAS No.
60-80-0
Chemical Name:
Antipyrine
Synonyms
Sedatin;Azophen;Fenazon;Phenylon;Sedatine;Anodynin;Auralgan;Azophene;Fenazone;Methozin
CBNumber:
CB8200943
Molecular Formula:
C11H12N2O
Formula Weight:
188.23
MOL File:
60-80-0.mol

Antipyrine Properties

Melting point:
109-111 °C(lit.)
Boiling point:
319 °C
Density 
1,19 g/cm3
refractive index 
1.5850 (estimate)
storage temp. 
Refrigerator
solubility 
H2O: soluble1 gm in less than 1ml
form 
Crystalline Powder
pka
pKa 1.4 (Uncertain)
color 
White
Water Solubility 
1000 g/L (20 ºC)
Merck 
14,716
BRN 
157775
Stability:
Stable. Incompatible with ammonia, strong acids, alkalies, strong oxidizing agents, metallic salts, phenol.
CAS DataBase Reference
60-80-0(CAS DataBase Reference)
NIST Chemistry Reference
Antipyrine(60-80-0)
EPA Substance Registry System
3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-2- phenyl-(60-80-0)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36-37/39
RIDADR  3249
WGK Germany  1
RTECS  CD2450000
10
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29331190
Toxicity LD50 orally in rats: 1.8 g/kg (Hart)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P330 Rinse mouth.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P405 Store locked up.
P501 Dispose of contents/container to..…

Antipyrine price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 10784 Antipyrine tested according to Ph.Eur. 60-80-0 100g $77.2 2018-11-13 Buy
Sigma-Aldrich 1040005 Antipyrine United States Pharmacopeia (USP) Reference Standard 60-80-0 200mg $348 2018-11-13 Buy
TCI Chemical D1876 2,3-Dimethyl-1-phenyl-5-pyrazolone >99.0%(GC)(T) 60-80-0 25g $18 2018-11-22 Buy
TCI Chemical D1876 2,3-Dimethyl-1-phenyl-5-pyrazolone >99.0%(GC)(T) 60-80-0 500g $137 2018-11-22 Buy
Alfa Aesar A11089 Antipyrine, 98% 60-80-0 500g $81.8 2018-11-13 Buy

Antipyrine Chemical Properties,Uses,Production

Chemical Properties

White Powder

Uses

Analgesic; used to test hepatic drug-metabolizing activity.

Definition

ChEBI: A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at C-1 and C-5 and with a phenyl group at N-2.

brand name

Aerol;Antigestin;Asthma dellipsoids;Aurafair;Auralgicin;Auraltone;Bajumol;Breezeazy;Calmasmin;Cetussan;Codalgin;Crema antisolar evanescente;Doleron novum;Dolo-med-much;Dol-stop;Kalopsis;Lanceotic;Lavylgan;Mig-antos;Migranin;Natt-lunedon;Neo-felsol;Orecil;Otipyrin;Otosan-sulfan;Otothricinol;Palacaine;Pasta antisola;Pomada heridas;Prednefrin;Prefrin liquifilm;Prefrin z;Priatan;Prophyllen;Remolmed;Salicopil;Sedaural;Sedonan;Shhe 21;Spalt n;Tympagesic;Visublefarite.

World Health Organization (WHO)

Phenazone is a pyrazolone derivative chemically related to aminophenazone. Some regulatory authorities have imposed restrictions on its use on these grounds. However, a recent international study showed no statisticallybased evidence of an association with agranulocytosis or aplastic anaemia. Nor does it share with aminophenazone the propensity to produce potentially carcinogenic nitrosamines.

Safety Profile

A human Doison bv 1 i an unspecified route. Moderately toxic via ingestion, subcutaneous, and intravenous routes. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Enzyme inhibitor

This antipyretic agent (FW = 188.23 g/mol; CAS 60-80-0; pKa = 1.4; IUPAC Name: 1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one), also known as antipyrine, nonselectively inhibits COX-1 and COX-2, showing little anti-inflammatory activity. It was first synthesized in 1884, more than a decade before the much-heralded synthesis of acetylsalicylic acid. See Antipyretic Agents Phenbenicillin, See Fenbenicillin

Purification Methods

Antipyrine crystallises from EtOH/water mixture, *benzene, *benzene/pet ether or hot water (charcoal), and the crystals are dried under a vacuum. [Beilstein 24 H 27, 24 III/IV 75.]

Antipyrine Preparation Products And Raw materials

Raw materials

Preparation Products


Antipyrine Suppliers

Global( 250)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21930 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 541 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23983 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20094 58

View Lastest Price from Antipyrine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-10 Antipyrine
60-80-0
US $22.40 / KG 1KG 99% 10T career henan chemical co
2018-09-26 Antipyrine/Phenazone cas:60-80-0
60-80-0
US $10.00 / G 10G 99% 10mt Hubei XinRunde Chemical Co., Ltd.

Antipyrine Spectrum


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