5-(Dimethylamino)uracil synthesis
2synthesis methods
- Product Name:5-(Dimethylamino)uracil
- CAS Number:37454-51-6
- Molecular formula:C6H9N3O2
- Molecular Weight:155.15
Yield:37454-51-6 69%
Reaction Conditions:
in tetrahydrofuran at 100; for 16 h;Autoclave;
Steps:
13
A solution of 5-bromopimidine-2,4(1H,3H)-dione 1 (1.5 g, 7.85 mmol) in Me2NH (15 mL, 2 M in THF) was stirred in autoclave at 100 °C for 16 h. Theresulting mixture was cooled down to room temperature and concentrated in vacuum, the residue was washed with water and dried to give 5- (dimethylamino)pyrimidine-2,4(1H,3H)-dione 2 (840 mg, 69%) as a yellow solid. LRMS (M + H) m/z: calcd 156.07; found 156. ‘H NMR (300 MHz, DMSO) 5: 11.00 (s, 1H), 10.41 (s, 1H), 6.65 (s, 1H), 2.52 (s, 6H).
References:
WO2015/89218,2015,A1 Location in patent:Page/Page column 122