2-Amino-4,6-dimethylpyrimidine synthesis
- Product Name:2-Amino-4,6-dimethylpyrimidine
- CAS Number:767-15-7
- Molecular formula:C6H9N3
- Molecular Weight:123.16
Yield:767-15-7 75%
Reaction Conditions:
with sodium carbonate in water at 60; for 0.5 h;Sonication;Reagent/catalyst;Time;
Steps:
General procedure for the sonochemical synthesis of 2-aminopyrimidine derivatives
General procedure: Into the round-bottom reaction vessels having an appropriate thickness for the sonochemicalreactions; guanidine hydrochloride (0.052 mol) and corresponding β-diketone compound (0.052 mol) were placed in water (15 mL) and Na2CO3 (0.052 mol). The reaction vessel has been put in a hot water bath at 60°C, and the flask content was exposed to ultrasonic waves for 30 min. The solid product obtained at the end of the experiment was treated with a small quantity of water and filtered through the Nuche funnel. 2-Amino-4,6-dimethylpyrimidine (1) White solid, yield: 75%, m.p.: 152-155 C (Lit. m.p.: 153 C).24 FT-IR (KBr), max/cm1:3395-3310 (s, NH2 stretching), 3175 (w, aromatic, C-H stretching), 1633 (w, N-Hbending), 1575, 1537 (conjugated CC stretching), 1459, 1381 (aliphatic C-H bending),1243 (C-NH2 stretching), 1026, 952, 793. MS (DI) m/z (%) calcd for C6H9N3:123.1; found: 123. 1H-NMR (CDCl3, 400 MHz) d: 2.25 (s, 6H, CH3), 5.36 (bs, 2H,NH2), 6.33 (s, 1H, Ar-H).
References:
Bayramoğlu, Duygu;Kurtay, Gülbin;Güllü, Mustafa [Synthetic Communications,2020,vol. 50,# 5,p. 649 - 658]
