5-FLUORO-2,3-DIHYDRO-1,4-BENZODIOXINE synthesis
- Product Name:5-FLUORO-2,3-DIHYDRO-1,4-BENZODIOXINE
- CAS Number:69464-49-9
- Molecular formula:C8H7FO2
- Molecular Weight:154.14
363-52-0
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106-93-4
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$15.00/5g
69464-49-9
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$60.00/250mg
Yield:69464-49-9 95.8%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 80; for 24 h;
Steps:
14 Synthesis of compound 14-d
Dissolve 3-fluorocatechol (2g, 15.63mmol) in N,N-dimethylformamide (10mL), add anhydrous potassium carbonate (6.5g, 46.89mmol) and 1,2-dibromoethyl Alkane (14.7 g, 78.15 mmol). The reaction mixture was heated to 80°C and stirred for 24 hours.After cooling to room temperature, the reaction mixture was poured into ice water (100 mL), extracted with petroleum ether (100 mL×2), the organic phase was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to obtain a light brown oil 14- d(2.3g, yield: 95.8%). This product does not require further purification.
References:
CN111714628,2020,A Location in patent:Paragraph 0443-0450
363-52-0
207 suppliers
$7.00/250mg
107-04-0
270 suppliers
$9.00/1g
69464-49-9
19 suppliers
$60.00/250mg