5-Hydroxypyrimidine synthesis
- Product Name:5-Hydroxypyrimidine
- CAS Number:26456-59-7
- Molecular formula:C4H4N2O
- Molecular Weight:96.09
99984-35-7
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26456-59-7
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Yield:-
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in methanol at 20;
Steps:
D136 pyrimidin-5-ol To a solution of 5-[(phenylmethyl)oxy]pyrimidine (2.43 g, 13.0 mmol) in methanol (20 mL) was added Pd/C (10 % Pd/C, 10 % on carbon). The reaction mixture was stirred at room temperature under H2 atmosphere over weekend, then filtered and concentrated. The residue was used into next step without purification.
References:
GLAXO GROUP LIMITED;WAN, Zehong;ZHANG, Xiaomin;TONG, Zhaolong;LONG, Kai;DOWDELL, Sarah E.;MANAS, Eric Steven;GOODMAN, Krista Beaver WO2012/37782, 2012, A1 Location in patent:Page/Page column 58-59
31458-33-0
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26456-59-7
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109299-78-7
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26456-59-7
151 suppliers
$18.00/250mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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14221-01-3
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109299-78-7
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26456-59-7
151 suppliers
$18.00/250mg
1000210-73-0
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1000210-73-0
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