5-Methoxy-4-chromanone synthesis

5synthesis methods

Product Name:5-Methoxy-4-chromanone
CAS Number:863309-86-8
Molecular formula:C10H10O3
Molecular Weight:178.18

49855-03-0
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$28.60/5MG

42327-52-6 Synthesis

4H-1-BENZOPYRAN-4-ONE, 2,3-DIHYDRO-7-METHOXY-

42327-52-6
86 suppliers
$45.00/10mg

863309-86-8
35 suppliers
$377.00/250mg

Yield:863309-86-8 67%

Reaction Conditions:

with PPA at 67; for 1 h;

Steps:

1; 3

3-(2-Methoxyphenoxy)propanoic acid (5.61 mmol) and polyphosphoric (25 ml_) are combined and heated at 67 ⁰C for 1 h. The reaction mixture is diluted with ice water (150 ml_) and the precipitated solids are collected by filtration, washed with water, and dried to provide 8-methoxy-2,3-dihydrochromen-4-one (Target C2) in 67% yield as a brown solid.

References:

WO2009/55437,2009,A2 Location in patent:Page/Page column 59; 60

150-19-6 Synthesis