5-Methoxy-4-chromanone synthesis
- Product Name:5-Methoxy-4-chromanone
- CAS Number:863309-86-8
- Molecular formula:C10H10O3
- Molecular Weight:178.18
49855-03-0
42327-52-6
863309-86-8
General procedure for the synthesis of 7-methoxy-4H-1-benzopyran-4-one and 5-methoxy-4-isodihydrochromanone from 3-(3-methoxyphenoxy)propionic acid: 3-(2-methoxyphenoxy)propionic acid (5.61 mmol) was mixed with polyphosphoric acid (25 mL) and the reaction was heated for 1 hr at 67 °C. After completion of the reaction, the reaction mixture was diluted with ice water (150 mL) and the precipitated solid product was collected by filtration. Subsequently, the solid was washed with water and dried to afford 8-methoxy-2,3-dihydro-4-one (target compound C2) in 67% yield as a brown solid.
49855-03-0
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863309-86-8
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$377.00/250mg
Yield:863309-86-8 67%
Reaction Conditions:
with PPA at 67; for 1 h;
Steps:
1; 3
3-(2-Methoxyphenoxy)propanoic acid (5.61 mmol) and polyphosphoric (25 ml_) are combined and heated at 67 0C for 1 h. The reaction mixture is diluted with ice water (150 ml_) and the precipitated solids are collected by filtration, washed with water, and dried to provide 8-methoxy-2,3-dihydrochromen-4-one (Target C2) in 67% yield as a brown solid.
References:
WO2009/55437,2009,A2 Location in patent:Page/Page column 59; 60
150-19-6
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863309-86-8
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863309-86-8
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863309-86-8
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863309-86-8
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