2'-HYDROXY-6'-METHOXYACETOPHENONE synthesis
- Product Name:2'-HYDROXY-6'-METHOXYACETOPHENONE
- CAS Number:703-23-1
- Molecular formula:C9H10O3
- Molecular Weight:166.17
Yield: 96%
Reaction Conditions:
Stage #1:2,6-dihydroxylacetophenone with potassium carbonate in acetone for 0.166667 h;
Stage #2:dimethyl sulfate in acetone for 6 h;Reflux;
Steps:
1
15.5 g of compound (1)And anhydrous K2C0315. 18 g were placed in 250 mL of dry acetone (80 mL)Of a round bottom flask,Magnetic stirring with constant pressure dropping funnel lOminDimethyl sulphate was added dropwise15. 12gRefluxed for 6 h.Cooled to room temperature,The pH was adjusted to 2 with hydrochloric acid, extracted with ethyl acetate,The organic layers were combined, washed with water,Saturated saline wash,Dried over anhydrous sodium sulfate,Concentrated, recrystallized from methanol yellow crystals 15. 93g,Yield 96%.
References:
Guangxi Teachers Education University;HUANG, CHUSHENG;CHEN, JICHANG;LIU, HONGXING;SUN, ZHUO CN103570661, 2016, B Location in patent:Paragraph 0017-0018
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