5-Methoxypentanoic acid methyl ester synthesis
- Product Name:5-Methoxypentanoic acid methyl ester
- CAS Number:52546-36-8
- Molecular formula:C7H14O3
- Molecular Weight:146.18
5454-83-1
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Yield:52546-36-8 97.8%
Reaction Conditions:
with sodium methylate in methanol;
Steps:
173 6-Ethyl-1,4-dihydro-2-(4-methoxybutyl)-5-(N-methyl)carboxamido-4-(4-nitrophenyl)-3-{N-[3-(4,4-diphenylpiperidin-1-yl)propyl]}carboxamidopyridine (173)
EXAMPLE 173 6-Ethyl-1,4-dihydro-2-(4-methoxybutyl)-5-(N-methyl)carboxamido-4-(4-nitrophenyl)-3-{N-[3-(4,4-diphenylpiperidin-1-yl)propyl]}carboxamidopyridine (173) A solution of methyl 5-bromovalerate (10.0 g, 51.3 mmol), NaOMe (12.3 ml of 25% solution, 53.8 mmol) in 100 ml of MeOH was refluxed for 5 hrs. The MeOH was removed in vacuo and residue was partitioned between CHCl3 (200 ml) and water (50 ml). The organic layer was separated and washed with water (100 ml). After drying (Na2 SO4) and evaporation of solvent, methyl 5-methoxyvalerate (7.33 g, 97.8%) was obtained as a colorless oil.
References:
US5767131,1998,A
1119-46-6
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52546-36-8
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14273-86-0
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