ChemicalBook CAS DataBase List 5-Methyl-3-nitromethyl-hexanoic Acid, Ethyl Ester

5-Methyl-3-nitromethyl-hexanoic Acid, Ethyl Ester synthesis

4synthesis methods

Product Name:5-Methyl-3-nitromethyl-hexanoic Acid, Ethyl Ester
CAS Number:128013-65-0
Molecular formula:C10H19NO4
Molecular Weight:217.26

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Hexanoic acid, 3-bromo-5-methyl-, ethyl ester

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5-Methyl-3-nitromethyl-hexanoic Acid, Ethyl Ester

128013-65-0
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Yield:128013-65-0 96%

Reaction Conditions:

with 1,8-diazabicyclo[5.4.0]undec-7-ene at 0 - 30; for 2.5 h;

Steps:

(+/-) Ethyl 5-methyl-3-nitromethyl-hexanoateTo a solution of (+/-) ethyl 5-methyl-3-bromo-hexanoate (leq) in nitromethane (4vol) at 0-S°C was added DBU (l.OSeq) dropwise over 30 minutes. After completion of the addition, the reaction mixture was allowed to attain 25-30⁰C and stirred at this temperature for 2 hours. After completion of the reaction, the reaction mixture was poured into a mixture of cone. HCl (0.4vol) and water (15vol) and stirred for 15 minutes. The reaction mixture was extracted with ethyl acetate and the combined organic extracts were washed with water. The combined organic layer was dried over sodium sulfate and concentrated under reduced pressure to give the product as yellow oil. Molar yield = 96%.

References:

WO2009/81208,2009,A1 Location in patent:Page/Page column 24

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1071-46-1 Synthesis