2-thioxo-3-[4-(trifluoromethyl)phenyl]-1,3-thiazolidin-4-one synthesis
- Product Name:2-thioxo-3-[4-(trifluoromethyl)phenyl]-1,3-thiazolidin-4-one
- CAS Number:57669-54-2
- Molecular formula:C10H6F3NOS2
- Molecular Weight:277.29
1645-65-4
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$10.00/1g
68-11-1
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$12.00/25g
57669-54-2
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$189.00/500mg
Yield:57669-54-2 54%
Reaction Conditions:
in methanol;water; for 4 h;Reflux;
Steps:
5.1.16. 3-(4-(Trifluoromethyl)phenyl)-2-thioxothiazolidin-4-one (12h)
A solution of 4-(trifluoromethyl)phenyl isothiocyanate (609 mg, 3.0 mmol), 2-mercaptoacetic acid (300 mg, 3.25 mmol) in methanol (10 mL), and water (20 mL) was heated to reflux for 4 h. After cooling to room temperature, the mixture was poured into water, and the solid was filtered out and purified by flash silica column [gradual eluant: EtOAc/petroleum ether, 0-40%] to afford 450 mg of 12h, pale-yellow solid, 54% yield. Mp 140-142 °C; 1H NMR δ ppm 7.82 (d, 2H, J = 8.4 Hz, ArH-2, 6), 7.38 (d, 2H, J = 8.4 Hz, ArH-3, 5), 4.23 (s, 2H, SCH2); MS m/z 276 (M-1, 100).
References:
He, Xiao-Yang;Zou, Peng;Qiu, Jiayin;Hou, Ling;Jiang, Shibo;Liu, Shuwen;Xie, Lan [Bioorganic and Medicinal Chemistry,2011,vol. 19,# 22,p. 6726 - 6734] Location in patent:experimental part
455-14-1
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6326-83-6
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57669-54-2
13 suppliers
$189.00/500mg
455-14-1
520 suppliers
$5.00/10g
57669-54-2
13 suppliers
$189.00/500mg
![Carbamodithioic acid, N-[4-(trifluoromethyl)phenyl]-, compd. with 1,4-diazabicyclo[2.2.2]octane (1:1)](/CAS/20211123/GIF/1430796-50-1.gif)
1430796-50-1
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57669-54-2
13 suppliers
$189.00/500mg
1645-65-4
143 suppliers
$10.00/1g
57669-54-2
13 suppliers
$189.00/500mg