N-[2-amino-5-(phenylthio)phenyl]-2-methoxyacetamide synthesis
- Product Name:N-[2-amino-5-(phenylthio)phenyl]-2-methoxyacetamide
- CAS Number:58306-67-5
- Molecular formula:C15H16N2O2S
- Molecular Weight:288.36
![2-methoxy-N-[2-nitro-5-(phenylthio)phenyl]acetamide](/CAS/GIF/63470-85-9.gif)
63470-85-9
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Yield:58306-67-5 94.2%
Reaction Conditions:
with hydrogen in methanol at 25 - 35; under 750.075 - 3750.38 Torr; for 12 h;Autoclave;Temperature;Solvent;
Steps:
1.3; 2.3; 3.3; 4.3; 5.3; 6.3 (3) Preparation of 2-amino-5-phenylthio-(2-methoxy)acetanilide:
(3) Preparation of 2-amino-5-phenylthio-(2-methoxy)acetanilide: The 2-nitro-5-phenylthio-(2-methoxy) acetanilide (32.0g), Base iron/nickel supported catalyst (content 10%, 3.2g) and methanol (200ml) added to 500ml stainless steel In the autoclave, start stirring, first replace with nitrogen three times and then replace three times with hydrogen, and finally pass hydrogen to the internal pressure of the reactor The force is 0.5MPa; maintain the temperature of the reactor at 25-35°C and the internal pressure at 0.1~0.5MPa, stir and react for 12 hours until the reaction is complete; The reaction solution was filtered and the filtrate was collected, and purified water (100ml) was added dropwise while stirring, then the temperature was lowered to 0~5°C, and stirring was continued for 1 hour. Filter and collect the precipitated crystals, wash and dry to obtain 2-amino-5-phenylsulfanyl-(2-methoxy)acetanilide, purity> 99.0%, the yield was 94.2%.
References:
CN108299259,2018,A Location in patent:Page/Page column 5-8
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