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Description Uses Toxicity
Chlorobenzene structure
Chemical Name:
cp27;NSC 8433;U.N. 1134;NCI-C54886;tetrosinsp;Abluton T30;Chlorbenzen;Chlorbenzol;Chlorbenzene;Chlorobenzen
Molecular Formula:
Formula Weight:
MOL File:

Chlorobenzene Properties

Melting point:
-45 °C
Boiling point:
132 °C(lit.)
vapor density 
3.86 (vs air)
vapor pressure 
11.8 mm Hg ( 25 °C)
refractive index 
n20/D 1.524(lit.)
Flash point:
75 °F
storage temp. 
water: soluble0.207 g/L at 20°C
APHA: ≤30
Relative polarity
explosive limit
Water Solubility 
0.4 g/L (20 ºC)
λ: 288 nm Amax: 1.0
λ: 290 nm Amax: 0.40
λ: 300 nm Amax: 0.05
λ: 325 nm Amax: 0.04
λ: 360-400 nm Amax: 0.01
Henry's Law Constant
1.11, 1.54, 1.81, 2.80, and 3.79 at 2.0, 6.0, 10.0, 18.0, and 25.0 °C, respectively (EPICS-SPME, Dewulf et al., 1999)(x 10-3 atm?m3/mol)
Exposure limits
TLV-TWA 75 ppm (~345 mg/m3) (ACGIH, MSHA, OSHA, and NIOSH); IDLH 2400 ppm.
Stable. Incompatible with oxidizing agents. Flammable. Attacks some types of plastics, rubber and coatings.
CAS DataBase Reference
108-90-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, chloro-(108-90-7)
EPA Substance Registry System
Benzene, chloro-(108-90-7)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H302+H332-H319-H336-H341-H372-H373-H410-H225-H301-H311-H331-H370-H226-H315-H332-H411-H351-H301+H311+H331
Precautionary statements  P201-P202-P233-P240-P241+P242+P243-P264-P270-P271-P273-P301+P312+P330-P302+P352+P332+P313+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P308+P313-P391-P403+P233-P280a-P303+P361+P353-P304+P340-P501a-P210-P260-P280-P301+P310-P311-P261-P370+P378-P281
Hazard Codes  Xn,N,T,F
Risk Statements  10-20-51/53-40-39/23/24/25-23/24/25-11
Safety Statements  24/25-61-36/37-45-16-7
RIDADR  UN 1134 3/PG 3
WGK Germany  2
RTECS  CZ0175000
Autoignition Temperature 590 °C
HazardClass  3
PackingGroup  III
HS Code  29039190
Toxicity LD50 orally in Rabbit: 2000 - 4000 mg/kg

NFPA 704

Diamond Hazard Value Description
3 0
Health   3 Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
Flammability   3 Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone)
Instability   0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)

(NFPA, 2010)

Chlorobenzene price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 08650 Chlorobenzene analytical standard 108-90-7 5ml-f $53 2018-11-13 Buy
Sigma-Aldrich 08650 Chlorobenzene analytical standard 108-90-7 25ml-f $211 2018-11-13 Buy
Alfa Aesar 022921 Chlorobenzene, Spectrophotometric Grade, 99.9% 108-90-7 *4x1L $273 2018-11-16 Buy
Alfa Aesar 022921 Chlorobenzene, Spectrophotometric Grade, 99.9% 108-90-7 1L $78.3 2018-11-16 Buy
Sigma-Aldrich 101389 Chlorobenzene ReagentPlus , 99% 108-90-7 1l $91.5 2018-11-13 Buy

Chlorobenzene Chemical Properties,Uses,Production


Chlorobenzene is a monocyclic aromatic compound with one hydrogen atom on the benzene ring substituted with one chlorine. It is produced by chlorination of benzene in the liquid phase with a catalyst. Chlorobenzene is a colourless, flammable liquid with a sweet almond-like odor, at ambient temperature with a relatively high vapour pressure, moderate octanol-water partition coefficient (log 2.8) and moderate to low water solubility (497.9 mg/L @ 25℃). Chlorobenzene has a high solubility in nonpolar solvents, however, it is almost insoluble in water. Technical grade Chlorobenzene is typically 99% pure with < 0.05% benzene and < 0.1% dichlorobenzenes as contaminants. It is a common solvent and a widely used intermediate in the manufacture of other chemicals. Rhodococcus phenolicus is a bacterium species able to degrade chlorobenzene as sole carbon sources.


  1. Chlorobenzene is used primarily as raw material for the synthesis of o- and p-nitrochlorobenzene and 2,4-dinitrochlorobenzene.Important quantitative chemical conversions other than the production of nitrochlorobenzenes are the production of diphenyl oxide and diphenyldichlorosilane.
  2. Chlorobenzene is mainly used as raw material for the synthesis of chemicals including triphenylphosphine (catalyst for organic synthesis), phenylsilane, and thiophenol (pesticide and pharmaceutical intermediate). It is also used as raw material for the synthesis of solvent for organic synthesis reactions including methylenediphenyldiisocyanate, urethane raw material, agricultural adjuvants, paint and ink, and cleaning solvent for electronics.
  3. manufacture of phenol, aniline, DDT; solvent for paints; heat transfer medium.
  4. Chlorobenzene is used as a process solvent in the production of isocyanates such as MDI and TDI and as a solvent in various crop protection formulations. It is further used as a solvent in condensation reactions in the dyes industry.
  5. Chlorobenzene is a basic substance used in chemical syntheses with 95% of the quantity used converted in closed systems to intermediate and final products.
  6. It is used as a process solvent in the manufacture of three indigoid dyes and pigments. All the pigments and dyes are thioindigoid colors.
  7. Chlorobenzene is an example of haloarenes which is formed by mono substitution of benzene ring. When chlorobenzene is fused with sodium hydroxide at 623K and 320 atm sodium phenoxide is produced. Finally, sodium phenoxide on acidification gives phenols.
    Preparation of phenols from Chlorobenzene


The toxic effects of chlorobenzene on humans were exhaustion, nausea, lethargy, headache and irritation to the upper respiratory tract and eye. Contact of chlorobenzene with the skin induced irritation. No reports were obtained on sensitization by chlorobenzene in this investigation.
The oral LD50 values of chlorobenzene were 1,445 mg/kg in mice, 1,427 to 3,400 mg/kg in rats and 2,250 to 2,830 mg/kg in rabbits. The LC50s following 6-hr inhalation exposure were 1,889 ppm in mice and 2,968 ppm in rats.

Chemical Properties

colourless liquid, Chlorination of benzene in the presence of a catalyst (FeCl3 or AICI3) yields chlorobenzene as the first product. Substitution with a second CI yields ortho, para, or meta dichlorobenzene, Eventually all the hydrogens can be substituted to give hexachlorobenzene, C6C16. In the presence ofultraviolet light, the chlorinationofbenzene yields benzene hexachloride, C6H6C~, a derivative ofcyclohexane.

Chemical Properties

Chlorobenzene, also called monochlorobenzene, is a monocyclic aromatic compound. It is a colorless liquid with an aromatic almond-like odor and is manufactured for use as a solvent, is used in the production of other chemicals (pesticides), and in making certain other chemicals, rubber, dyes and grease solvents. It is used as a feedstock to produce ortho- and para- nitrochlorobenzenes and aniline; as a solvent for paints; and as a heat transfer medium. In the past,Chlorobenzene was used as an intermediate in phenol and DDT production. Chlorobenzene enters the environment from industrial and municipal discharges. Another potential source is the formation and emission of Chlorobenzene as a product of incomplete combustion in waste incinerators.
Chlorobenzene is moderately soluble in water; up to 1,000 milligrams will mix with a liter of water. Chlorobenzene is slightly persistent in water, with a half-life of between 2 to 20 days. Chlorobenzene persists in soil (several months), in air (3.5 days), and water (less than 1 day).
When heated to decomposition this compound emits toxic fumes of hydrogen chloride gas, CO and CO2. Common synonyms are Monochlorobenzene, Benzene Chloride, and Chlorobenzol. It is incompatible with strong oxidizing agents and dimethyl sulfoxide.
Chlorobenzene (also best known as monochlorobenzene or MCB) is a flammable liquid. Companies also use MCB to make adhesives, paints, paint removers, polishes, dyes, and drugs. In the past companies have used MCB to make phenol and related chemicals, pesticides (like DDT), and aniline.
Chlorobenzene can evaporate when exposed to air. It dissolves slightly when mixed with water. Effects of chlorobenzene on human health and the environment depend on how much chlorobenzene is present and the length and frequency of exposure. Effects also depend on the health of a person or the condition of the environment when exposure occurs.

Physical properties

Clear, colorless, flammable liquid with a sweet almond, medicinal or mothball-like odor. An odor threshold concentration of 210 ppbv was reported by Leonardos et al. (1969). At 40 °C, the lowest concentration at which an odor was detected was 190 μg/L. At 25 °C, the lowest concentration at which a taste was detected was 190 μg/L (Young et al., 1996). The average least detectable odor threshold concentration in water at 60 °C was 0.08 mg/L (Alexander et al., 1982). Cometto-Mu?iz and Cain (1994) reported an average nasal pungency threshold concentration of 10,553 ppmv.


Chlorobenzene is used as a solvent for paints,as a heat transfer medium, and in the manu facture of phenol and aniline.


Chlorobenzene is a halogenated benzene used in chemical toxicity QSAR research for agricultural pollution.


ChEBI: The simplest member of the class of monochlorobenzenes, that is benzene in which a single hydrogen has been substituted by a chlorine.


A colorless liquid made by the catalytic reaction of chlorine with benzene. It can be converted to phenol by reaction with sodium hydroxide under extreme conditions (300°C and 200 atmospheres pressure). It is also used in the manufacture of other organic compounds.

General Description

A colorless to clear, yellowish liquid with a sweet almond-like odor. Flash point 84°F. Practically insoluble in water and somewhat denser than water (9.2 lb / gal). Vapors heavier than air. Used to make pesticides, dyes, and other chemicals.

Air & Water Reactions

Highly flammable. Insoluble in water.

Reactivity Profile

Chlorobenzene undergoes a sometimes explosive reaction with powdered sodium or phosphorus trichloride + sodium. May react violently with dimethyl sulfoxide. Reacts vigorously with oxidizing agents. Attacks some forms of plastic, rubber and coatings. Forms a shock sensitive solvated salt with silver perchlorate. .


A possible carcinogen. Avoid inhalation and skin contact. Moderate fire risk. Explosive limits 1.8–9.6%.

Health Hazard

Irritating to skin, eyes and mucous membranes. Repeated exposure of skin may cause dermatitis due to defatting action. Chronic inhalation of vapors or mist may result in damage to lungs, liver, and kidneys. Acute vapor exposures can cause symptoms ranging from coughing to transient anesthesia and central nervous system depression.
Limited information is available on the acute (short-term) effects of chlorobenzene. Acute inhalation exposure of animals to chlorobenzene produced narcosis, restlessness, tremors, and muscle spasms. Chronic (long-term) exposure of humans to chlorobenzene affects the central nervous system (CNS). Signs of neurotoxicity in humans include numbness, cyanosis, hyperesthesia (increased sensation), and muscle spasms. No information is available on the carcinogenic effects of chlorobenzene in humans. EPA has classified chlorobenzene as a Group D, not classifiable as to human carcinogenicity.

Fire Hazard

Flammable liquid; flash point (closed cup) 29°C (84°F); vapor pressure 8.8 torr at 20°C (68°F); autoignition temperature 638°C (1180°F).
Chlorobenzene vapors form explosive mixtures with air within the range 1.3-7.1% by volume in air. Dimethyl sulfoxide decom poses violently in contact with chloroben zene (NFPA 1997). Many metal perchlorates, such as those of silver and mercury, may form shock-sensitive solvated perchlorates that may explode on impact.

Safety Profile

Suspected carcinogen. Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. Mutation data reported. Strong narcotic with slight irritant qualities. Dichlorobenzols are strongly narcotic. Little is known of the effects of repeated exposures at lower concentrations, but it may cause hdney and liver damage. The industrial illnesses reported may possibly be due to nitrobenzol. Dangerous fire hazard when exposed to heat or flame. Moderate explosion hazard when exposed to heat or flame. Potentially explosive reaction with powdered sodium or phosphorus trichloride + sodtum. Violent reaction with AgClO4. Reacts vigorously with oxidizers. See also CHLORINATED HYDROCARBONS, AROMATIC. To fight fire, use foam, CO2, dry chemical, water to blanket fire. Associated with EPA Superfund sites

Potential Exposure

Chlorobenzene is used in the manufacture of aniline, phenol, and chloronitrobenzene; as an intermediate in the manufacture of dyestuffs and many pesticides, as a solvent; and emulsifier.

Environmental Fate

Biological. In activated sludge, 31.5% of the applied chlorobenzene mineralized to carbon dioxide after 5 d (Freitag et al., 1985). A mixed culture of soil bacteria or a Pseudomonas sp. transformed chlorobenzene to chlorophenol (Ballschiter and Scholz, 1980). Pure microbial cultures isolated from soil hydroxylated chlorobenzene to 2- and 4-chlorophenol (Smith and Rosazza, 1974). Chlorobenzene was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum. At a concentration of 5 mg/L, biodegradation yields at the end of 1 and 2 wk were 89 and 100%, respectively. At a concentration of 10 mg/L, significant


UN1134 Chlorobenzene, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

The main impurities are likely to be chlorinated impurities originally present in the *benzene used in the synthesis of chlorobenzene, and also unchlorinated hydrocarbons. A common purification procedure is to wash it several times with conc H2SO4 then with aqueous NaHCO3 or Na2CO3, and water, followed by drying with CaCl2, K2CO3 or CaSO4, then with P2O5, and distilling. It can also be dried with Linde 4A molecular sieve. Passage through, and storage over, activated alumina has been used to obtain low conductance material. [Flaherty & Stern J Am Chem Soc 80 1034 1958, Beilstein 5 H 199, 5 IV 640.]


Reacts violently with strong oxidizers; dimethyl sulfoxide; sodium powder; silver perchlorate; causing fire and explosion hazard. Attacks some plastics, rubber, and coatings. Decomposes on heating, producing phosgene and hydrogen chloride fumes.

Waste Disposal

Incineration, preferably after mixing with another combustible fuel; care must be exercised to assure complete combustion to prevent the formation of phosgene; an acid scrubber is necessary to remove the halo acids produced.

Chlorobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

Chlorobenzene Suppliers

Global( 299)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
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Chlorobenzene Spectrum

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