ETHYL 2-ACETAMIDO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE synthesis
- Product Name:ETHYL 2-ACETAMIDO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE
- CAS Number:5919-29-9
- Molecular formula:C13H17NO3S
- Molecular Weight:267.34
![ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE](/CAS/GIF/4506-71-2.gif)
4506-71-2
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108-24-7
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5919-29-9
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Yield:5919-29-9 100%
Reaction Conditions:
in acetic acid at 85; for 24 h;
Steps:
10.4 (4) Synthesis of Ethyl 2-Acetylamino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-ca rboxylate
A mixture of ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxyl ate (25 g, 111 mmol), acetic acid (150 mL), and acetic anhydride (19 mL, 200 mmol) was stirred at 85°C for 24 hours. To this reaction solution, 100 mL of water was added, and the precipitates were collected by filtration to obtain ethyl 2-acetylamino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-ca rboxylate (30 g, quant.) as a white solid: TLC Rf=0.38 (n-hexane/ethyl acetate=3/1); 1H NMR (500 MHz, CDCl3) δ 1.38 (t, J=7.0 Hz, 3H), 1.76-1.81 (m, 4H), 2.25 (s, 3H), 2.63 (t, J=4.5 Hz, 2H), 2.76 (t, J=4.5 Hz, 2H), 4.32 (q, J=7.0 Hz, 2H), 11.26 (br s, 1H); 13C NMR (126 MHz, CDCl3) δ 14.5, 23.1, 23.2, 23.9, 24.6, 26.6, 60.7, 111.5, 126.9, 130.9, 147.8, 166.9, 167.1.
References:
EP2813226,2014,A1 Location in patent:Paragraph 0157; 0158
4506-71-2
201 suppliers
$6.00/1g
75-36-5
577 suppliers
$17.92/100G
5919-29-9
26 suppliers
$45.00/50mg
4506-71-2
201 suppliers
$6.00/1g
5919-29-9
26 suppliers
$45.00/50mg
![2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/4815-29-6.gif)
4815-29-6
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$6.00/250mg
108-24-7
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$14.00/250ML
5919-29-9
26 suppliers
$45.00/50mg
105-56-6
455 suppliers
$10.00/5ml
5919-29-9
26 suppliers
$45.00/50mg