6,7-Difluoroquinazolin-4-ol synthesis
- Product Name:6,7-Difluoroquinazolin-4-ol
- CAS Number:205259-37-6
- Molecular formula:C8H4F2N2O
- Molecular Weight:182.13
122-51-0
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205259-37-6
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Yield:205259-37-6 90%
Reaction Conditions:
in methanol at 80; for 24 h;Cooling with ice;Solvent;Temperature;
Steps:
1.2 (2) Preparation of 6,7-difluoro-3,4-dihydroquinazolin-4-one
2-amino-4,5-difluorobenzamide(44.0g, 0.26mol) dissolved in methanol (700mL),Ice bath cooling,Slowly add trimethyl orthoformate (27.5g, 0.26mol),Reaction at 80 for 24h,Down to room temperature,Rotate under reduced pressure to dryness,Dichloromethane extraction,Wash with salt water,Dry with anhydrous sodium sulfate,Rotate under reduced pressure to dryness,The crude product is recrystallized by ethyl acetate-petroleum ether mixed solvent,To obtain 6,7-difluoro-3,4-dihydroquinazolin-4-one,Off-white solid (42.0g),90% yield
References:
CN111763214,2020,A Location in patent:Paragraph 0040; 0044; 0045; 0046
83506-93-8
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60100-09-6
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205259-37-6
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$45.00/25mg
83506-93-8
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$10.00/250mg
3473-63-0
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205259-37-6
20 suppliers
$45.00/25mg
211374-80-0
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149-73-5
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$12.00/5g
205259-37-6
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$45.00/25mg
83506-93-8
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$10.00/250mg
6313-33-3
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205259-37-6
20 suppliers
$45.00/25mg