ChemicalBook CAS DataBase List 6-Acetoxy-4-chloro-7-methoxyquinazoline

6-Acetoxy-4-chloro-7-methoxyquinazoline synthesis

14synthesis methods

Product Name:6-Acetoxy-4-chloro-7-methoxyquinazoline
CAS Number:230955-75-6
Molecular formula:C11H9ClN2O3
Molecular Weight:252.65

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one

199327-61-2
271 suppliers
$6.00/1g

230955-75-6
149 suppliers
$11.00/250mg

Yield:230955-75-6 93.7%

Reaction Conditions:

with sulfuryl dichloride in acetonitrile at 55;Temperature;Concentration;

Steps:

1
1) exchange resin 12.8g in D301 macroporous weakly basic styrene anion, 6- (2-morpholino-ethoxy) -7-methoxy-3,4-dihydro-quinazolin-4 ketone (31.9g, 100mol), sulfuryl chloride (16.2g, 120mmol) in 100ml acetonitrile were contact reaction, the contact reaction temperature was 55 , after the reaction was quenched with ice-water, extracted with methylene chloride, concentrated under reduced pressure to give 6-acetoxy-4-chloro-7-methoxy-quinazoline of 31.7g, a yield of 93.7%, a purity of 99.05%.

References:

Chen, Hong;He, Baohong CN105541737, 2016, A Location in patent:Paragraph 0026; 0034

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179688-53-0 Synthesis