6-bromo-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one synthesis
- Product Name:6-bromo-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one
- CAS Number:949008-41-7
- Molecular formula:C10H10BrNO2
- Molecular Weight:256.1
23426-63-3
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40925-68-6
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949008-41-7
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Yield:-
Reaction Conditions:
with potassium carbonate in acetone at 20; for 18 h;
Steps:
1 Step 1:
To a solution of methyl 2-bromo-2-methylpropanoate (0.438 g, 2.42 mmol) and 2-amino- 4-bromophenol (0.35 g, 1.9 mmol) in acetone (18.6 ml) was added potassium carbonate (0.257 g, 1.86 mmol). The reaction was allowed to stir for 18 h at room temperature. The reaction was filtered, and the solvent removed under reduced pressure. The material was purified by column chromatography on silica(0-100% EtO Ac/Hex) to afford 6-bromo-2,2-dimethyl-2H- benzo[b][l,4]oxazin-3(4H)-one. MS: 256 and 258 (M + 1).
References:
WO2021/126728,2021,A1 Location in patent:Page/Page column 84
364-73-8
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949008-41-7
33 suppliers
$33.00/250mg