6-BROMO-2-METHYL-3,4-DIHYDROQUINAZOLIN-4-ONE synthesis
- Product Name:6-BROMO-2-METHYL-3,4-DIHYDROQUINAZOLIN-4-ONE
- CAS Number:5426-59-5
- Molecular formula:C9H7BrN2O
- Molecular Weight:239.07
64-17-5
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5426-59-5
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Yield: 97%
Reaction Conditions:
with tert.-butylhydroperoxide in dimethyl sulfoxide at 25 - 35; for 40 h;Irradiation;Green chemistry;
Steps:
1. General information. General experimental procedure for the synthesis of quinazolinones:
General procedure: a 10-mL glass tube was filled with the required 2-aminobenzamide (0.2 mmol), alcohol (0.5 mmol), and TBHP (1 equiv.) and irradiated at room temperature with an 18 W blue LED for 40 h. After reaction completion (monitored by TLC), water was added to the reaction solution and the mixture was extracted with EtOAc. The combined organic layers were dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude product was purified by silica-gel column chromatography using petroleum ether/ethyl acetate as eluent to give the desired product.
References:
Xie, Zongbo;Lan, Jin;Zhu, Haibo;Lei, Gaoyi;Jiang, Guofang;Le, Zhanggao [Chinese Chemical Letters,2021,vol. 32,# 4,p. 1427 - 1431] Location in patent:supporting information
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5794-88-7
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5426-59-5
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19165-25-4
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5426-59-5
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189634-99-9
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21740-00-1
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124-42-5
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5426-59-5
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$22.00/250mg