6-bromo-7-methoxy-4(3H)-Quinazolinone synthesis
- Product Name:6-bromo-7-methoxy-4(3H)-Quinazolinone
- CAS Number:950577-05-6
- Molecular formula:C9H7BrN2O2
- Molecular Weight:255.07
Yield:950577-05-6 72%
Reaction Conditions:
with ammonium formate at 165; for 18 h;
Steps:
1.1
A solution of methyl 2-amino-5-bromo-4-methoxybenzoate (75 mg, 0.29 mmol) and ammonium formate (38 mg, 0.8 mmol) in formamide (1 mL) was heated at 165 °C for 18h. The mixture was allowed to cool to room temperature then diluted with an excess of water. The solid formed was collected by filtration and washed with water then ethyl acetate and dried to give 6-bromo-7-methoxyquinazolin-4(3H)-one (53 mg, 72% yield) as a pale yellow solid. MS (EI) for C9H7BrN2O2: 255, 257 (MH+).
References:
WO2010/135524,2010,A1 Location in patent:Page/Page column 190
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