
6-chloro-4-methoxy-1(2)H-pyrazolo[3,4-d]pyrimidine synthesis
- Product Name:6-chloro-4-methoxy-1(2)H-pyrazolo[3,4-d]pyrimidine
- CAS Number:98138-75-1
- Molecular formula:C6H5ClN4O
- Molecular Weight:184.58

67-56-1
782 suppliers
$9.00/25ml
![4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine](/CAS/GIF/42754-96-1.gif)
42754-96-1
216 suppliers
$7.00/100mg
![6-chloro-4-methoxy-1(2)H-pyrazolo[3,4-d]pyrimidine](/CAS/20180713/GIF/98138-75-1.gif)
98138-75-1
23 suppliers
inquiry
Yield:98138-75-1 120 mg
Reaction Conditions:
with potassium carbonate at 20; for 24 h;
Steps:
1 Step 1: Synthesis of 6-chloro-4-methoxy-lH-pyrazolo [3, 4-d] pyrimidine:
To a solution of 4,6-dichloro-lH-pyrazolo[3,4-d]pyrimidine 1 (330 mg, 1.74 mmol) in methanol (10 mL) was added potassium carbonate (240 mg, 1.74 mmol). After the mixture was stirred at rt for 24 h, the reaction was quenched with saturated ammonium chloride (30 mL) solution and extracted with EA (20 mL x 3). The combined organic layer was dried over sodium sulfate (30 g), filtered and concentrated. The residue was purified by silica gel chromatography (eluent: EA/n-Hex = 1/10) to afford 120 mg of the title compound. LC-MS (Method A) (ESI+): m/z 185 (M+H)+; 1H-NMR (300 MHz, CDCb) d 10.69 (br s, 1H), 8.09 (s, 1H), 4.19 (s, 3H).
References:
WO2020/132269,2020,A1 Location in patent:Paragraph 0487

124-41-4
726 suppliers
$12.00/25g
![4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine](/CAS/GIF/42754-96-1.gif)
42754-96-1
216 suppliers
$7.00/100mg
![6-chloro-4-methoxy-1(2)H-pyrazolo[3,4-d]pyrimidine](/CAS/20180713/GIF/98138-75-1.gif)
98138-75-1
23 suppliers
inquiry

2465-59-0
170 suppliers
$31.00/250mg
![6-chloro-4-methoxy-1(2)H-pyrazolo[3,4-d]pyrimidine](/CAS/20180713/GIF/98138-75-1.gif)
98138-75-1
23 suppliers
inquiry

50270-27-4
256 suppliers
$23.00/1g
![6-chloro-4-methoxy-1(2)H-pyrazolo[3,4-d]pyrimidine](/CAS/20180713/GIF/98138-75-1.gif)
98138-75-1
23 suppliers
inquiry