(6-(Methoxymethyl)pyridin-2-yl)methanol synthesis
- Product Name:(6-(Methoxymethyl)pyridin-2-yl)methanol
- CAS Number:136133-18-1
- Molecular formula:C8H11NO2
- Molecular Weight:153.18
890904-66-2
35 suppliers
$61.00/100mg
136133-18-1
11 suppliers
inquiry
Yield:136133-18-1 70.4%
Reaction Conditions:
with methanol;sodium tetrahydridoborate at 0 - 20; for 2 h;
Steps:
26.1 Step-1 : (6-(methoxymethyl)pyridin-2-yl)methanol
To a solution of 6-(methoxymethyl)pyridine-2-carbaldehyde (450.00 mg, 2.977 mmol) in MeOH (10.00 mL) was added NaBT (112.6 mg, 2.977 mmol) in portions at 0 °C. The resulting mixture was stirred at room temperature for 2 h. The reaction mixture was then quenched by the addition of water and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum to afford (6- (methoxymethyl)pyridin-2-yl)methanol (338 mg, 70.4%) as a yellow oil. MS (ESI) calc’d for (C7H8C1NO) (M+l)+, 154.1, found 154.1.
References:
WO2022/118210,2022,A1 Location in patent:Page/Page column 146-147
1195-59-1
376 suppliers
$6.00/1g
74-88-4
352 suppliers
$15.00/10g
64726-18-7
0 suppliers
inquiry
136133-18-1
11 suppliers
inquiry
108-48-5
485 suppliers
$9.90/190μL
136133-18-1
11 suppliers
inquiry
499-83-2
640 suppliers
$6.00/10g
136133-18-1
11 suppliers
inquiry