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Chemical Properties Usage Preparation Category Toxicity grade Acute toxicity Flammability hazard characteristics Storage Fire extinguishing agents
2,6-Lutidine structure
Chemical Name:
26L;utidine;NSC 2155;FEMA 3540;2,6-LUTIDINE;2,6-Lutdeine;2,6-Lutidene;2,6-Lutidine>FEMA NUMBER 3540;2,6-LUTIDINE 99%
Molecular Formula:
Formula Weight:
MOL File:

2,6-Lutidine Properties

Melting point:
-6 °C
Boiling point:
143-145 °C(lit.)
0.92 g/mL at 25 °C(lit.)
vapor pressure 
5.5 hPa (20 °C)
refractive index 
n20/D 1.497(lit.)
Flash point:
92 °F
storage temp. 
6.65(at 25℃)
Water Solubility 
40 g/100 mL (20 ºC)
JECFA Number
Stable. Flammable. Incompatible with strong oxidizing agents, acid chlorides, acids, chloroformates. Protect from moisture.
CAS DataBase Reference
108-48-5(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)
EWG's Food Scores
NIST Chemistry Reference
Pyridine, 2,6-dimethyl-(108-48-5)
EPA Substance Registry System
2,6-Dimethylpyridine (108-48-5)
  • Risk and Safety Statements
Signal word  Warning
Hazard statements  H335-H226-H302-H315-H319
Precautionary statements  P210-P301+P312+P330-P305+P351+P338-P370+P378-P280h
Hazard Codes  Xn,F,Xi
Risk Statements  10-22-36/37/38-20/21/22
Safety Statements  26-36/37-16-36-36/37/39
RIDADR  UN 1993 3/PG 3
WGK Germany  3
RTECS  OK9700000
Hazard Note  Irritant/Flammable
HazardClass  3
PackingGroup  III
HS Code  29333999
Toxicity LD50 orally in Rabbit: 400 mg/kg LD50 dermal Rabbit > 1000 mg/kg

2,6-Lutidine price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 336106 2,6-Lutidine purified by redistillation, ≥99% 108-48-5 1l $222 2020-08-18 Buy
Sigma-Aldrich 04991 2,6-Lutidine analytical standard 108-48-5 5ml-f $112 2020-08-18 Buy
TCI Chemical L0067 2,6-Lutidine >98.0%(GC) 108-48-5 25mL $15 2020-06-24 Buy
TCI Chemical L0067 2,6-Lutidine >98.0%(GC) 108-48-5 500mL $75 2020-06-24 Buy
Alfa Aesar A10478 2,6-Lutidine, 98+% 108-48-5 25ml $17.6 2020-06-24 Buy

2,6-Lutidine Chemical Properties,Uses,Production

Chemical Properties

Colorless oily liquid, melting point-5.8℃, boiling point 144℃(139-141℃,145.6-145.8℃), density 0.9252(20/4℃), refractive index 1.4977, flash point 33℃, soluble in dimethyl formamide, tetrahydrofuran, cold water, hot water, ethanol and ether, with mixed odor of Pyridine and mint.


2,6-Lutidine is widely used in organic synthesis as a raw material and solvent. In Pharmaceutical industry, it can be used for the production of antiatherosclerotic pyridinolcarbamate. It can also be used for the production of Cortisone acetate, hydrocortisone, niacin, lobeline and stilbazium iodide which is an anthelmintic and effective for the worm, fasciolopsis buski, whipworm, pinworm and so on. In addition, 2,6-Lutidine can be used as an auxiliaries for Pesticides, dyes, dyeing and printing and used as resin and rubber accelerator,  intermediate of hot oil stabilizer.  It  can be oxidized to produce Dimethyl pyridine acid, which can be used as the stabilizer for hydrogen peroxide and acetic acid and used to synthesize lobelidine. 2,6-Lutidine is used as various kinds of nutty essence and cocoa, coffee, meat, bread and vegetable typed essence. It is also used to synthesize drugs for the treatment and first-aid of hypertension.


2,6-Lutidine is obtained through the separation of β-methylpyridine which is a recycled product of coal coking byproduct.


flammable liquid

Toxicity grade

high toxic

Acute toxicity

oral – rat LD50: 400mg/kg

Flammability hazard characteristics

flammable in case of fire, high temperature and oxidant, releasing toxic nitrogen oxides in case of heat.


Ventilated and dry warehouse with low temperature, separated from acids.

Fire extinguishing agents

Dry powder, dry sand, carbon dioxide, foam.

Chemical Properties

Colorless to yellow liquid

Chemical Properties

2,6-Dimethylpyridine has a powerful and diffusive minty-tarry odor. It has also been described to have the odor of pyridine and peppermint


Reported found in bread, tea, peppermint oil, cheeses, chicken, beef, pork, beer, sherry, whiskies, cocoa, coffee, tea, oatmeal, rice bran, buckwheat and malt.


Isolated from the basic fraction of coal tar. A semi-volatile compound in tobacco.


ChEBI: A member of the class of methylpyridines that is pyridine carrying methyl substituents at positions 2 and 6.

Taste threshold values

Taste characteristics at 20 ppm: nutty, coffee, cocoa, musty, bready and meaty

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 2, p. 214, 1943
Tetrahedron Letters, 17, p. 383, 1976 DOI: 10.1016/S0040-4039(00)93738-9

General Description

A colorless liquid with a peppermint odor. Flash point 92°F. Less dense than water. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Soluble in water.

Reactivity Profile

2,6-Lutidine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Chemical Synthesis

Synthesis from ethyl acetoacetate, formaldehyde and ammonia; isolated from basic fraction of coal tar

Purification Methods

Likely contaminants include 3-and 4-picoline (similar boiling points). However, they are removed by using BF3, with which they react preferentially, by adding 4mL of BF3 to 100mL of dry fractionally distilled 2,6-lutidine and redistilling. Distillation of commercial material from AlCl3 (14g per 100mL) can also be used to remove picolines (and water). Alternatively, lutidine (100mL) can be refluxed with ethyl benzenesulfonate (20g) or ethyl p-toluenesulfonate (20g) for 1hour, then the upper layer is cooled, separated and distilled. The distillate is refluxed with BaO or CaH2, then fractionally distilled through a glass helices-packed column. 2,6-Lutidine can be dried with KOH or sodium or by refluxing with (and distilling from) BaO, prior to distillation. For purification via its picrate, 2,6-lutidine, dissolved in absolute EtOH, is treated with an excess of warm ethanolic picric acid. The precipitate is filtered off, recrystallised from acetone (to give m 163-164.5o (166-167o), and partitioned between ammonia and CHCl3/diethyl ether. The organic layer, after washing with dilute aqueous KOH, is dried with Na2SO4 and fractionally distilled. [Warnhoff J Org Chem 27 4587 1962.] Alternatively, 2,6-lutidine can be purified via its urea complex, as described under 2,3-lutidine. Other purification procedures include azeotropic distillation with phenol [Coulson et al. J Appl Chem (London) 2 71 1952], fractional crystallisation by partial freezing, and vapour-phase chromatography using a 180-cm column of polyethylene glycol-400 (Shell, 5%) on Embacel (May and Baker) at 100o, with argon as carrier gas [Bamford & Block J Chem Soc 4989 1961]. The hydrochloride has m 235-237o, 239o (from EtOH). [Beilstein 20 II 160, 20 III/IV 2776, 20/6 V 32.]

2,6-Lutidine Preparation Products And Raw materials

Raw materials

Preparation Products

2,6-Lutidine Suppliers

Global( 336)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21841 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22624 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 CHINA 1365 55
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 CHINA 24886 60
career henan chemical co
+86-371-86658258 CHINA 30039 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28231 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 10311 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114 CHINA 6371 58

Related articles

View Lastest Price from 2,6-Lutidine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-18 2,6-Lutidine
US $1.00 / kg 1kg as customer's need 500kg career henan chemical co
2018-08-03 2,6-Lutidine
US $16.00 / KG 1KG 99% 1000KG career henan chemical co

2,6-Lutidine Spectrum

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