ChemicalBook CAS DataBase List 6-Methoxynicotinic acid

6-Methoxynicotinic acid synthesis

13synthesis methods

Product Name:6-Methoxynicotinic acid
CAS Number:66572-55-2
Molecular formula:C7H7NO3
Molecular Weight:153.14

26218-80-4 Synthesis

26218-80-4
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$7.00/1g

66572-55-2
168 suppliers
$15.00/5g

Yield: 92%

Reaction Conditions:

with sodium hydroxide;water in methanol at 70; for 1.5 h;

Steps:

A2.1
NaOH (0.36 g, 9.0 mmol) was dissolved in MeOH (5 itiL)' and water (5 mL) . Methyl 6-methoxynicotinate (1.0Og, 5.98 mmol) was added and the mixture was stirred at 70⁰C for 90 minutes. The solution was cooled and diluted with IN NaOH (25 mL) . The solution was extracted with EtOAc and the separated aqueous layer was acidified to pH 1. The aqueous layer was extracted with EtOAc (3 times) and the combined organic layers were dried and concentrated to yield 6-methoxynicotinic acid as a white solid (0.849, 92%): m/z (APCI pos) 154.1 (100%) (M+H).

References:

TAKEDA PHARMACEUTICAL COMPANY LIMITED WO2008/11131, 2008, A2 Location in patent:Page/Page column 138-139