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6-Methoxynicotinaldehyde

6-Methoxynicotinaldehyde structure

CAS No.: 65873-72-5

Chemical Name:: 6-Methoxynicotinaldehyde

Synonyms: 6-METHOXYNICOTINALDEHYDE;6-Methxoynicotinaldehyde;3-FORMYL-6-METHOXYPYRIDINE;5-FORMYL-2-METHOXYPYRIDINE;6-METHOXY-3-NICOTINALDEHYDE;6-Methoxy-3-pyridinecarbaldehyde;6-METHOXY-PYRIDINE-3-CARBALDEHYDE;6-methoxy-3-pyridinecorbaxaldehyde;6-METHOXY-3-PYRIDINECARBOXALDEHYDE;2-METHOXYPYRIDINE-5-CARBOXALDEHYDE

CBNumber:: CB3390560

Molecular Formula:: C7H7NO2

Molecular Weight:: 137.14

MDL Number:: MFCD02683446

MOL File:: 65873-72-5.mol

MSDS File:: SDS

Last updated:2026-04-22 18:57:36

Product description	Number	Pack Size	Price
6-Methoxy-3-pyridinecarboxaldehyde 98%	533068	1g	$37.5
6-Methoxy-3-pyridinecarboxaldehyde 98%	533068	5g	$133
6-Methoxy-3-pyridinecarboxaldehyde >98.0%(GC)	M2347	1g	$53
6-Methoxy-3-pyridinecarboxaldehyde >98.0%(GC)	M2347	5g	$176
5-FORMYL-2-METHOXY-PYRIDINE 97%	64881	5G	$28
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6-Methoxynicotinaldehyde Properties

Melting point	51-54 °C (lit.)
Boiling point	65-70 °C(Press: 12 Torr)
Density	1.159±0.06 g/cm3(Predicted)
Flash point	225 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	1.60±0.10(Predicted)
form	Crystalline Powder
color	Off-white to light yellow
Water Solubility	insoluble
InChI	InChI=1S/C7H7NO2/c1-10-7-3-2-6(5-9)4-8-7/h2-5H,1H3
InChIKey	CTAIEPPAOULMFY-UHFFFAOYSA-N
SMILES	C1=NC(OC)=CC=C1C=O
CAS DataBase Reference	65873-72-5(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HazardClass

IRRITANT

HS Code

29339900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

6-Methoxynicotinaldehyde price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	533068	6-Methoxy-3-pyridinecarboxaldehyde 98%	65873-72-5	1g	$37.5	2026-04-30	Buy
Sigma-Aldrich	533068	6-Methoxy-3-pyridinecarboxaldehyde 98%	65873-72-5	5g	$133	2026-04-30	Buy
TCI Chemical	M2347	6-Methoxy-3-pyridinecarboxaldehyde >98.0%(GC)	65873-72-5	1g	$53	2026-04-30	Buy
TCI Chemical	M2347	6-Methoxy-3-pyridinecarboxaldehyde >98.0%(GC)	65873-72-5	5g	$176	2026-04-30	Buy
AstaTech	64881	5-FORMYL-2-METHOXY-PYRIDINE 97%	65873-72-5	5G	$28	2026-04-30	Buy

Product number	Packaging	Price	Buy
533068	1g	$37.5	Buy
533068	5g	$133	Buy
M2347	1g	$53	Buy
M2347	5g	$176	Buy
64881	5G	$28	Buy

6-Methoxynicotinaldehyde Chemical Properties,Uses,Production

Chemical Properties

off-white to light yellow crystalline powder

Uses

Substrate used in a synthesis of flavanones via an L-proline-catalyzed condensation with o-hydroxyarylketones.

Uses

An intermediate for the synthesis of the somatostatic sst3 receptor.

General Description

6-Methoxy-3-pyridinecarboxaldehyde, also known as 6-methoxy-3-nicotinaldehyde, can be prepared from 5-bromo-2-methoxypyridine.

Synthesis

13472-85-0

68-12-2

65873-72-5

At -78 °C, N-butyllithium (50 mL, 2.5 M hexane solution) was slowly added dropwise to a solution of 5-bromo-2-methoxypyridine (22.4 g, 119.1 mmol) in anhydrous tetrahydrofuran (240 mL). After the dropwise addition, the reaction mixture was continued to be stirred at -78 °C for 90 min. Subsequently, N,N-dimethylformamide (18.5 mL, 238.3 mmol) was added slowly dropwise and stirring was continued for 90 min at -78 °C. Upon completion of the reaction, the mixture was slowly warmed to room temperature. The reaction mixture was poured into saturated sodium bicarbonate solution (1000 mL) and extracted with ether (3 x 250 mL). The organic phases were combined, dried with magnesium sulfate, filtered and concentrated to dryness to give 15.4 g (94% yield) of 6-methoxy-3-pyridinecarboxaldehyde as a light yellow solid. The product was characterized by 1H NMR (DMSO-d6): δ= 9.97 (s, 1H), 8.77 (m, 1H), 8.12 (dd, 1H, J = 8.6, 2.3 Hz), 6.99 (d, 1H, J = 8.7 Hz), 3.97 (s, 3H).LC/MS analysis (Method A): retention time = 0.25 min, purity = 92.8%, calculated mass = 137, [M + H]+ = 138. HPLC analysis (Method C): retention time = 4.9 min, purity = 95.9% (210-370 nm) and 98.7% (256 nm).

References

[1] Synthesis, 2012, vol. 44, # 5, p. 735 - 746
[2] Journal of medicinal chemistry, 2004, vol. 47, # 20, p. 4829 - 4837
[3] Patent: US2006/19965, 2006, A1. Location in patent: Page/Page column 27
[4] Synthesis, 1994, # 1, p. 87 - 92
[5] Synlett, 2009, # 15, p. 2508 - 2512

6-Methoxynicotinaldehyde Preparation Products And Raw materials

Raw materials

Nitrogen N,N-Dimethylformamide 2-Methoxypyridine Sodium acetate trihydrate Sodium sulfate

Sodium Tetrahydrofuran Diethyl ether Ethyl acetate 2,5-Dibromopyridine

Sodium bicarbonate 5-Bromo-2-methoxypyridine Bromine Acetic acid n-Butyllithium

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Preparation Products

6-Methoxynicotinic acid (6-methoxypyridin-3-yl)methanol 3-Pyridinecarboxaldehyde,1,6-dihydro-1-(1-methylethyl)-6-oxo-(9CI)

6-Methoxynicotinaldehyde Suppliers

Global( 327)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Joy Biotech Ltd.	+86-15968534750 +86-1358845959750	sales@joybiotech.com	China	1000	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2176	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58

Supplier	Advantage
Shanghai Joy Biotech Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
HaBo Hong Kong Co., Limited.	58
Changzhou Ditong Chemical Co.,Ltd	58
Shandong chuangyingchemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58

View Lastest Price from 6-Methoxynicotinaldehyde manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-22	6-Methyl-3-pyridinecarboxaldehyde 65873-72-5	US $29.00 / mg		99.90%	10g	TargetMol Chemicals Inc.
2025-11-18	6-Methoxynicotinaldehyde 65873-72-5	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2025-09-25	6-Methoxynicotinaldehyde 65873-72-5	US $200.00-1.00 / KG	1KG	99%, 99.5% Sublimated	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

6-Methyl-3-pyridinecarboxaldehyde
65873-72-5
US $29.00 / mg
99.90%
TargetMol Chemicals Inc.

6-Methoxynicotinaldehyde
65873-72-5
US $1.10 / g
99.00%
Dideu Industries Group Limited

6-Methoxynicotinaldehyde
65873-72-5
US $200.00-1.00 / KG
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

6-Methoxynicotinaldehyde Spectrum

6-Methoxynicotinaldehyde(65873-72-5)¹HNMR 6-Methoxynicotinaldehyde(65873-72-5)IR

65873-72-5(6-Methoxynicotinaldehyde)Related Search:

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2-METHOXYPYRIDINE-5-CARBOXALDEHYDE 5-FORMYL-2-METHOXYPYRIDINE 3-FORMYL-6-METHOXYPYRIDINE 6-METHOXY-3-NICOTINALDEHYDE 6-METHOXY-3-PYRIDINECARBOXALDEHYDE 6-METHOXYNICOTINALDEHYDE 6-METHOXY-PYRIDINE-3-CARBALDEHYDE 3-Pyridinecarboxaldehyde, 6-methoxy- (9CI) 2-methoxy-5-pyridinecarboxaldehyde 2-Methoxypyridine-5-carboxaldehyde, 5-Formyl-2-methoxypyridine 6-methoxy-3-pyridinecorbaxaldehyde 6-Methoxypyridine-3-carboxaldehyde, 98% 6-Methoxy-3-pyridinecarboxaldehyde ,97% 6-Methoxy-3-pyridinecarboxaldehyde,6-Methoxy-3-nicotinaldehyde 6-Methxoynicotinaldehyde 3-Pyridinecarboxaldehyde,6-Methoxy- 2-Methoxypyridine-5-carboxaldehyde, 5-Formyl-2-methoxypyridine, 6-Methoxypyridine-3-carboxaldehyde 6-Methoxy-3-pyridinecarboxaldehyde, 97% 1GR 6-Methoxypyridine-3-carboxaldehyde,98% 6-Methoxy-3-pyridinecarboxaldehyde 98% 6- Methoxy-3- pyridineforMaldehyde 6-Methoxy-3-pyridinecarbaldehyde 6-Methoxy-3-pyridinecarboxaldehyde> 6-Methoxynicotinaldehyde ISO 9001：2015 REACH 65873-72-5 658728-72-5 ALDEHYDE Pyridines Heterocyclic Building Blocks Building Blocks C7 and C8 Heterocycle-Pyridine series Aldehydes C6 to C7 C7 Carbonyl Compounds Chemical Synthesis Heterocyclic Building Blocks Organic Building Blocks Boronic Acid Building Blocks ALDEHYDE Pyridine pharmacetical Pyridine series Pyridines