(6-(Trifluoromethoxy)quinolin-8-yl)boronic acid synthesis
- Product Name:(6-(Trifluoromethoxy)quinolin-8-yl)boronic acid
- CAS Number:1089179-11-2
- Molecular formula:C10H7BF3NO3
- Molecular Weight:256.9737
121-43-7
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Yield:1089179-11-2 55%
Reaction Conditions:
with C6H5Li in tetrahydrofuran;dibutyl ether;soln. of PhLi in (n-Bu)2O was added to soln. of quinoline ligand in THF at -78°C under Ar over 5 min; stirred at -78°C for 1 h; B compd. was added slowly; warmed to ambient temp.; stirred for 4 h; aq. HCl added; washed (Et2O); aq. NaOH added to aq. layer; filtered; recrystd. (acetone/hexane);
References:
Tan, Runyu;Jia, Peng;Rao, Yingli;Jia, Wenli;Hadzovic, Alen;Yu, Qing;Li, Xia;Song, Datong [Organometallics,2008,vol. 27,# 24,p. 6614 - 6622]