ChemicalBook CAS DataBase List 7,8-Dihydroxycoumarin

7,8-Dihydroxycoumarin synthesis

9synthesis methods

Product Name:7,8-Dihydroxycoumarin
CAS Number:486-35-1
Molecular formula:C9H6O4
Molecular Weight:178.14

471-25-0
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$10.00/1g

87-66-1 Synthesis

87-66-1
632 suppliers
$6.00/10g

486-35-1
275 suppliers
$41.00/250mg

Yield:486-35-1 98%

Reaction Conditions:

with ytterbium(III) trifluoromethanesulfonate hydrate at 80; for 0.0333333 h;Microwave irradiation;Reagent/catalyst;

Steps:

General procedure for coumarin synthesis by MW irradiation
General procedure: An open reaction vessel containing a mixture of the phenol (1.0 mmol), propiolic acid (1.1 mmol), and Yb(OTf)₃ hydrate (0.1 mmol) was put in the MW apparatus and irradiated at 200 W (80 °C) for 2 min. The reaction was monitored by TLC (eluent CH₂Cl₂ / MeOH 99:1). The crude solid obtained was diluted with Et₂O and the resulting suspension filtered under vacuum to separate the catalyst, the precipitate washed several times with Et₂O. The filtrate was washed twice with a 5% NaHCO₃ solution (10 mL) dried over MgSO₄ and evaporated to dryness under vacuum yielding the desired product.

References:

Fiorito, Serena;Epifano, Francesco;Taddeo, Vito A.;Genovese, Salvatore [Tetrahedron Letters,2016,vol. 57,# 26,p. 2939 - 2942] Location in patent:supporting information

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617-48-1 Synthesis