ChemicalBook CAS DataBase List 7-benzyl-2,6-dichloro-7H-purine

7-benzyl-2,6-dichloro-7H-purine synthesis

11synthesis methods

Product Name:7-benzyl-2,6-dichloro-7H-purine
CAS Number:56025-87-7
Molecular formula:C12H8Cl2N4
Molecular Weight:279.12

100-44-7 Synthesis

100-44-7
659 suppliers
$13.50/250G

5451-40-1 Synthesis

5451-40-1
508 suppliers
$10.00/1g

79064-26-9 Synthesis

79064-26-9
54 suppliers
$36.00/250mg

56025-87-7
21 suppliers
$288.00/250mg

Yield:56025-87-7 10% ，79064-26-9 65%

Reaction Conditions:

Stage #1: 2,6-dichloropurinewith potassium carbonate in DMF (N,N-dimethyl-formamide); for 0.333333 h;
Stage #2: benzyl chloride in DMF (N,N-dimethyl-formamide); for 24 h;

Steps:

1 Synthesis of 9-benzyl-2,6-dichloro-9H-purine and 7-benzyl-2,6-dichloro-7H-purine

9-Benzyl-2,6-dichloro-9H-purine and 7-benzyl-2,6-dichloro-7H-purine were synthesized according to a method described in the literature: G. Langli; L. L. Gundersen and F. Rise, Tetrahedron 1996, 52 (15), 5625-5638. 2,6-Dichloropurine (18.9 g, 0.10 mol) and potassium carbonate (41.5 g, 0.30 mol) were added to DMF (500 mL) and the mixture was stirred under nitrogen atmosphere for 20 min. Benzylchloride (17.5 mL, 0.15 mol) was added and the mixture was further stirred for 24 hrs. After filtration, DMF was evaporated under reduced pressure, and the obtained reaction mixture was separated and purified by silica gel column chromatography to give 9-benzyl-2,6-dichloro-9H-purine (18.1 g, 64.8 mmol, yield 65%) and 7-benzyl-2,6-dichloro-7H-purine (2.79 g, 10.0 mmol, yield 10%).

References:

EP1595882,2005,A1 Location in patent:Page/Page column 16